Exonuclease 1

From Wikipedia, the free encyclopedia

Exonuclease 1

Identifiers

EXO1; HEX1; hExoI

External IDs

OMIM: 606063 MGI: 1349427 HomoloGene: 31352

Gene ontology
Molecular Function:	• DNA binding • endonuclease activity • ribonuclease H activity • exonuclease activity • protein binding • hydrolase activity • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity • flap endonuclease activity • double-stranded DNA specific 5'-3' exodeoxyribonuclease activity
Cellular Component:	• nucleus
Biological Process:	• DNA repair • nucleotide-excision repair • mismatch repair • DNA recombination • immune response • meiosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003686 (mRNA)
NP_003677 (protein)

NM_012012 (mRNA)
NP_036142 (protein)

Location

Chr 1: 240.08 - 240.12 Mb

Chr 1: 177.72 - 177.75 Mb

Pubmed search

[1]

[2]

Exonuclease 1, also known as EXO1, is a human gene.^[1]

This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: EXO1 exonuclease 1.

[edit] Further reading

Liberti SE, Rasmussen LJ (2005). "Is hEXO1 a cancer predisposing gene?". Mol. Cancer Res. 2 (8): 427–32. PMID 15328369.
Holle GE (1985). "[Pathophysiology of ulcer disease]". Langenbecks Archiv für Chirurgie 366: 81–7. PMID 2414623.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Wilson DM, Carney JP, Coleman MA, et al. (1998). "Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1.". Nucleic Acids Res. 26 (16): 3762–8. PMID 9685493.
Schmutte C, Marinescu RC, Sadoff MM, et al. (1998). "Human exonuclease I interacts with the mismatch repair protein hMSH2.". Cancer Res. 58 (20): 4537–42. PMID 9788596.
Tishkoff DX, Amin NS, Viars CS, et al. (1998). "Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination.". Cancer Res. 58 (22): 5027–31. PMID 9823303.
Qiu J, Qian Y, Chen V, et al. (1999). "Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance.". J. Biol. Chem. 274 (25): 17893–900. PMID 10364235.
Lee BI, Wilson DM (2000). "The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities.". J. Biol. Chem. 274 (53): 37763–9. PMID 10608837.
Rasmussen LJ, Rasmussen M, Lee B, et al. (2000). "Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis.". Mutat. Res. 460 (1): 41–52. PMID 10856833.
Wu Y, Berends MJ, Post JG, et al. (2001). "Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms.". Gastroenterology 120 (7): 1580–7. PMID 11375940.
Schmutte C, Sadoff MM, Shim KS, et al. (2001). "The interaction of DNA mismatch repair proteins with human exonuclease I.". J. Biol. Chem. 276 (35): 33011–8. doi:10.1074/jbc.M102670200. PMID 11427529.
Jäger AC, Rasmussen M, Bisgaard HC, et al. (2001). "HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes.". Oncogene 20 (27): 3590–5. doi:10.1038/sj.onc.1204467. PMID 11429708.
Genschel J, Bazemore LR, Modrich P (2002). "Human exonuclease I is required for 5' and 3' mismatch repair.". J. Biol. Chem. 277 (15): 13302–11. doi:10.1074/jbc.M111854200. PMID 11809771.
Lee Bi BI, Nguyen LH, Barsky D, et al. (2002). "Molecular interactions of human Exo1 with DNA.". Nucleic Acids Res. 30 (4): 942–9. PMID 11842105.
Sun X, Zheng L, Shen B (2002). "Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome.". Cancer Res. 62 (21): 6026–30. PMID 12414623.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jagmohan-Changur S, Poikonen T, Vilkki S, et al. (2003). "EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer.". Cancer Res. 63 (1): 154–8. PMID 12517792.
Sharma S, Sommers JA, Driscoll HC, et al. (2003). "The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein.". J. Biol. Chem. 278 (26): 23487–96. doi:10.1074/jbc.M212798200. PMID 12704184.
Alam NA, Gorman P, Jaeger EE, et al. (2004). "Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.". Cancer Genet. Cytogenet. 147 (2): 121–7. PMID 14623461.
Genschel J, Modrich P (2004). "Mechanism of 5'-directed excision in human mismatch repair.". Mol. Cell 12 (5): 1077–86. PMID 14636568.