EXOSC6

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Exosome component 6
PDB rendering based on 2nn6.
Available structures: 2nn6
Identifiers
Symbol(s) EXOSC6; EAP4; MTR3; Mtr3p; hMtr3p; p11
External IDs OMIM: 606490 MGI: 1919794 HomoloGene: 12469
Orthologs
Human Mouse
Entrez 118460 72544
Ensembl ENSG00000157344 n/a
Refseq NM_058219 (mRNA)
NP_478126 (protein)		 NM_028274 (mRNA)
NP_082550 (protein)
Location Chr 16: 68.84 - 68.84 Mb n/a
Pubmed search [1] [2]

Exosome component 6, also known as EXOSC6, is a human gene.[1]

This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.[1]

[edit] References

  1. ^ a b Entrez Gene: EXOSC6 exosome component 6.

[edit] Further reading

  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653-63. PMID 12419256. 
  • van Hoof A, Parker R (2002). "Messenger RNA degradation: beginning at the end.". Curr. Biol. 12 (8): R285-7. PMID 11967169. 
  • Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809-18. doi:10.1006/jmbi.2001.5265. PMID 11812149. 
  • Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451-64. PMID 11719186. 
  • Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177-84. doi:10.1074/jbc.M007603200. PMID 11110791. 
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