EXOC1

From Wikipedia, the free encyclopedia


Exocyst complex component 1
Identifiers
Symbol(s) EXOC1; BM-102; FLJ10893; SEC3; SEC3L1; Sec3p
External IDs OMIM: 607879 MGI: 2445020 HomoloGene: 41241
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55763 69940
Ensembl ENSG00000090989 n/a
Uniprot Q9NV70 n/a
Refseq NM_001024924 (mRNA)
NP_001020095 (protein)		 XM_001052151 (mRNA)
XP_001052151 (protein)
Location Chr 4: 56.41 - 56.47 Mb n/a
Pubmed search [1] [2]

Exocyst complex component 1, also known as EXOC1, is a human gene.[1]

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.[1]

[edit] References

  1. ^ a b Entrez Gene: EXOC1 exocyst complex component 1.

[edit] Further reading

  • Hsu SC, TerBush D, Abraham M, Guo W (2004). "The exocyst complex in polarized exocytosis.". Int. Rev. Cytol. 233: 243–65. doi:10.1016/S0074-7696(04)33006-8. PMID 15037366. 
  • Kee Y, Yoo JS, Hazuka CD, et al. (1998). "Subunit structure of the mammalian exocyst complex.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. PMID 9405631. 
  • Hsu SC, Hazuka CD, Roth R, et al. (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments.". Neuron 20 (6): 1111–22. PMID 9655500. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152. 
  • Brymora A, Valova VA, Larsen MR, et al. (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene.". J. Biol. Chem. 276 (32): 29792–7. doi:10.1074/jbc.C100320200. PMID 11406615. 
  • Matern HT, Yeaman C, Nelson WJ, Scheller RH (2001). "The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9648–53. doi:10.1073/pnas.171317898. PMID 11493706. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Inoue M, Chang L, Hwang J, et al. (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.". Nature 422 (6932): 629–33. doi:10.1038/nature01533. PMID 12687004. 
  • Moskalenko S, Tong C, Rosse C, et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions.". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
 This article on a gene on chromosome 4 is a stub. You can help Wikipedia by expanding it.