Ethanolamine-phosphate phospho-lyase

From Wikipedia, the free encyclopedia

In enzymology, an ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) is an enzyme that catalyzes the chemical reaction

ethanolamine phosphate + H₂O acetaldehyde + NH₃ + phosphate

Thus, the two substrates of this enzyme are ethanolamine phosphate and H₂O, whereas its 3 products are acetaldehyde, NH₃, and phosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is ethanolamine-phosphate phosphate-lyase (deaminating acetaldehyde-forming). Other names in common use include O-phosphoethanolamine-phospholyase, amino alcohol O-phosphate phospholyase, O-phosphorylethanol-amine phospho-lyase, and ethanolamine-phosphate phospho-lyase (deaminating). It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 4.2.3.2
• BRENDA references for 4.2.3.2 (Recommended.)
• PubMed references for 4.2.3.2
• PubMed Central references for 4.2.3.2
• Google Scholar references for 4.2.3.2
• Fleshood HL, Pitot HC (1970). "The metabolism of O-phosphorylethanolamine in animal tissues. I O-phosphorylethanolamine phospho-lyase: partial purification and characterization". J. Biol. Chem. 245: 4414–20. PMID 5498429. 
• Jones A, Faulkner A, Turner JM (1973). "Microbial metabolism of amino alcohols. Metabolism of ethanolamine and 1-aminopropan-2-ol in species of Erwinia and the roles of amino alcohol kinase and amino alcohol o-phosphate phospho-lyase in aldehyde formation". Biochem. J. 134: 959–68. PMID 4357716. 

[edit] External links

The CAS registry number for this enzyme class is 37290-88-3.

• IUBMB entry for 4.2.3.2

• KEGG entry for 4.2.3.2

• BRENDA entry for 4.2.3.2

• NiceZyme view of 4.2.3.2

• EC2PDB: PDB structures for 4.2.3.2

• PRIAM entry for 4.2.3.2

• PUMA2 entry for 4.2.3.2

• IntEnz: Integrated Enzyme entry for 4.2.3.2

• MetaCyc entry for 4.2.3.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050459: ethanolamine-phosphate phospho-lyase

• AMIGO entry for GO code 0050459: ethanolamine-phosphate phospho-lyase