Ethanolamine-phosphate cytidylyltransferase

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In enzymology, an ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) is an enzyme that catalyzes the chemical reaction

CTP + ethanolamine phosphate $\rightleftharpoons$ diphosphate + CDP-ethanolamine

Thus, the two substrates of this enzyme are CTP and ethanolamine phosphate, whereas its two products are diphosphate and CDP-ethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:ethanolamine-phosphate cytidylyltransferase. Other names in common use include phosphorylethanolamine transferase, ET, CTP-phosphoethanolamine cytidylyltransferase, phosphoethanolamine cytidylyltransferase, and ethanolamine phosphate cytidylyltransferase. This enzyme participates in aminophosphonate metabolism and glycerophospholipid metabolism.

[edit] References

IUBMB entry for 2.7.7.14
BRENDA references for 2.7.7.14 (Recommended.)
PubMed references for 2.7.7.14
PubMed Central references for 2.7.7.14
Google Scholar references for 2.7.7.14
KENNEDY EP, WEISS SB (1956). "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222: 193–214. PMID 13366993.
Sundler R (1975). "Ethanolaminephosphate cytidylyltransferase. Purification and characterization of the enzyme from rat liver". J. Biol. Chem. 250: 8585–90. PMID 241749.
Visedo-Gonzalez E, Dixon HB (1989). "2-Aminoethylarsonic acid as an analogue of ethanolamine phosphate Endowment of ethanolamine-phosphate cytidylyltransferase with CTP pyrophosphatase activity". Biochem. J. 260: 299–301. PMID 2549956.