Estrogen-related receptor alpha

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Estrogen-related receptor alpha
PDB rendering based on 1lo1.
Available structures: 1lo1, 1xb7
Identifiers
Symbol(s) ESRRA; ERR1; ERRa; ERRalpha; ESRL1; NR3B1
External IDs OMIM: 601998 MGI: 1346831 HomoloGene: 20941
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2101 26379
Ensembl ENSG00000173153 ENSMUSG00000024955
Uniprot P11474 Q3U110
Refseq NM_004451 (mRNA)
NP_004442 (protein)		 NM_007953 (mRNA)
NP_031979 (protein)
Location Chr 11: 63.83 - 63.84 Mb Chr 19: 6.98 - 6.99 Mb
Pubmed search [1] [2]

Estrogen-related receptor alpha (ERR-alpha), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor which is encoded by the gene ESRRA (EStrogen Related Receptor Alpha).[1]

The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1.[1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: ESRRA estrogen-related receptor alpha.

[edit] Further reading

  • Giguère V, Yang N, Segui P, Evans RM (1988). "Identification of a new class of steroid hormone receptors.". Nature 331 (6151): 91-4. doi:10.1038/331091a0. PMID 3267207. 
  • Wiley SR, Kraus RJ, Zuo F, et al. (1993). "SV40 early-to-late switch involves titration of cellular transcriptional repressors.". Genes Dev. 7 (11): 2206-19. PMID 8224847. 
  • Yang N, Shigeta H, Shi H, Teng CT (1996). "Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter.". J. Biol. Chem. 271 (10): 5795-804. PMID 8621448. 
  • Johnston SD, Liu X, Zuo F, et al. (1997). "Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements.". Mol. Endocrinol. 11 (3): 342-52. PMID 9058380. 
  • Sladek R, Bader JA, Giguère V (1997). "The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene.". Mol. Cell. Biol. 17 (9): 5400-9. PMID 9271417. 
  • Shi H, Shigeta H, Yang N, et al. (1997). "Human estrogen receptor-like 1 (ESRL1) gene: genomic organization, chromosomal localization, and promoter characterization.". Genomics 44 (1): 52-60. doi:10.1006/geno.1997.4850. PMID 9286700. 
  • Sladek R, Beatty B, Squire J, et al. (1998). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene.". Genomics 45 (2): 320-6. doi:10.1006/geno.1997.4939. PMID 9344655. 
  • Vanacker JM, Bonnelye E, Delmarre C, Laudet V (1998). "Activation of the thyroid hormone receptor alpha gene promoter by the orphan nuclear receptor ERR alpha.". Oncogene 17 (19): 2429-35. doi:10.1038/sj.onc.1202167. PMID 9824153. 
  • Zhang Z, Teng CT (2001). "Estrogen receptor alpha and estrogen receptor-related receptor alpha1 compete for binding and coactivator.". Mol. Cell. Endocrinol. 172 (1-2): 223-33. PMID 11165056. 
  • Eiler S, Gangloff M, Duclaud S, et al. (2001). "Overexpression, purification, and crystal structure of native ER alpha LBD.". Protein Expr. Purif. 22 (2): 165-73. doi:10.1006/prep.2001.1409. PMID 11437591. 
  • Zhou D, Chen S (2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif.". Nucleic Acids Res. 29 (19): 3939-48. PMID 11574675. 
  • Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.". Mol. Med. 8 (1): 56-64. PMID 11984006. 
  • Kraus RJ, Ariazi EA, Farrell ML, Mertz JE (2002). "Estrogen-related receptor alpha 1 actively antagonizes estrogen receptor-regulated transcription in MCF-7 mammary cells.". J. Biol. Chem. 277 (27): 24826-34. doi:10.1074/jbc.M202952200. PMID 11986328. 
  • Ichida M, Nemoto S, Finkel T (2003). "Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha).". J. Biol. Chem. 277 (52): 50991-5. doi:10.1074/jbc.M210262200. PMID 12397057. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Schreiber SN, Knutti D, Brogli K, et al. (2003). "The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).". J. Biol. Chem. 278 (11): 9013-8. doi:10.1074/jbc.M212923200. PMID 12522104. 
  • Igarashi M, Kawaguchi Y, Hirai K, Mizuno F (2003). "Physical interaction of Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) with human oestrogen-related receptor 1 (hERR1): hERR1 interacts with a conserved domain of EBNA-LP that is critical for EBV-induced B-cell immortalization.". J. Gen. Virol. 84 (Pt 2): 319-27. PMID 12560563. 
  • Sengupta K, Banerjee S, Saxena N, Banerjee SK (2003). "Estradiol-induced vascular endothelial growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway.". Int. J. Oncol. 22 (3): 609-14. PMID 12579315. 
  • Sumi D, Ignarro LJ (2004). "Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression.". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 14451-6. doi:10.1073/pnas.2235590100. PMID 14610283. 
  • Laganière J, Tremblay GB, Dufour CR, et al. (2004). "A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression.". J. Biol. Chem. 279 (18): 18504-10. doi:10.1074/jbc.M313543200. PMID 14978033. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD