Estriol

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Estriol
Identifiers
CAS number	[50-27-1]
PubChem	5756
MeSH	Estriol
Properties
Molecular formula	C18H24O3
Molar mass	288.39
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.

Levels of estriol in non-pregnant women do not change much after menopause, and levels are not significantly different from levels in men.

[edit] Use in screening

Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta.

If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a problem with the development of the child.^[1] It is included as part of the triple test.

Because many pathological conditions in a pregnant woman can cause deviations in estriol levels, these screenings are often seen as less definitive of fetal-placental health than non-stress testing. Conditions which can create false-positives and false-negatives in estriol testing for fetal distress include preeclampsia, anemia and impaired kidney function.^[2]

[edit] References

1. ^ OB77 at FPnotebook
2. ^ Deska Pagana, Kathleen; Pagana, Timothy J. (2002). Mosby's manual of Diagnostic and Laboratory Tests, 2nd Edition. 

v • d • e Sex hormones and related agents (primarily G03, also L02, H01C) - human endogenous in CAPS Progestogens: (receptor) PROGESTERONE,Dienogest, Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone Selective progesterone receptor modulator: Asoprisnil, CDB-4124 Antiprogestogen: Mifepristone Androgens: (receptor) TESTOSTERONE, Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, (see also anabolic steroids) Antiandrogens: Bicalutamide, Cyproterone, Dienogest, Flutamide, Nilutamide, Spironolactone Estrogens: (receptor) ESTRADIOL, ESTRIOL, ESTRONE, Chlorotrianisene, Dienestrol, Diethylstilbestrol, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate Selective estrogen receptor modulator: Afimoxifene, Arzoxifene, Bazedoxifene, Clomifene, Fulvestrant, Lasofoxifene, Raloxifene, Tamoxifen, Toremifene Aromatase inhibitor: Aminogluthetimide, Anastrozole, Atamestane, Exemestane, Formestane, Letrozole, Vorozole Gonadotropins: (FSHR/LHCGR) ovulation stim.: Clomifene, Urofollitropin Antigonadotropins: Danazol, Gestrinone GnRH: (receptor) agonist: Buserelin, Goserelin, Histrelin, Leuprorelin, Nafarelin, Triptorelin antagonist: Abarelix, Cetrorelix, Ganirelix