Estradiol 17alpha-dehydrogenase

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In enzymology, an estradiol 17alpha-dehydrogenase (EC 1.1.1.148) is an enzyme that catalyzes the chemical reaction

estradiol-17alpha + NAD(P)+ estrone + NAD(P)H + H⁺

The 3 substrates of this enzyme are estradiol-17alpha, NAD⁺, and NADP⁺, whereas its 4 products are estrone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase. Other names in common use include 17alpha-estradiol dehydrogenase, 17alpha-hydroxy steroid dehydrogenase, 17alpha-hydroxy steroid oxidoreductase, 17alpha-hydroxysteroid oxidoreductase, and estradiol 17alpha-oxidoreductase. This enzyme participates in androgen and estrogen metabolism.

[edit] References

• IUBMB entry for 1.1.1.148
• BRENDA references for 1.1.1.148 (Recommended.)
• PubMed references for 1.1.1.148
• PubMed Central references for 1.1.1.148
• Google Scholar references for 1.1.1.148
• Renwick AG, Engel LL (1967). "The partial purification of 17 alpha- and 17 beta-estradiol dehydrogenase activities from chicken liver". Biochim. Biophys. Acta. 146: 336–48. PMID 4383682. 

[edit] External links

The CAS registry number for this enzyme class is 9044-91-1.

• IUBMB entry for 1.1.1.148

• KEGG entry for 1.1.1.148

• BRENDA entry for 1.1.1.148

• NiceZyme view of 1.1.1.148

• EC2PDB: PDB structures for 1.1.1.148

• PRIAM entry for 1.1.1.148

• PUMA2 entry for 1.1.1.148

• IntEnz: Integrated Enzyme entry for 1.1.1.148

• MetaCyc entry for 1.1.1.148

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047881: estradiol 17-alpha-dehydrogenase

• AMIGO entry for GO code 0047881: estradiol 17-alpha-dehydrogenase