ESM1

From Wikipedia, the free encyclopedia

Endothelial cell-specific molecule 1

Identifiers

ESM1; endocan

External IDs

OMIM: 601521 MGI: 1918940 HomoloGene: 5107

Gene ontology
Molecular Function:	• protein binding • insulin-like growth factor binding • growth factor activity
Cellular Component:	• extracellular region
Biological Process:	• regulation of cell growth • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_007036 (mRNA)
NP_008967 (protein)

NM_023612 (mRNA)
NP_076101 (protein)

Location

Chr 5: 54.31 - 54.32 Mb

n/a

Pubmed search

[1]

[2]

Endothelial cell-specific molecule 1, also known as ESM1, is a human gene.^[1]

This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals.^[1]

[edit] References

^ ^a ^b Entrez Gene: ESM1 endothelial cell-specific molecule 1.

[edit] Further reading

Lassalle P, Molet S, Janin A, et al. (1996). "ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines.". J. Biol. Chem. 271 (34): 20458–64. PMID 8702785.
Bechard D, Meignin V, Scherpereel A, et al. (2000). "Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies.". J. Vasc. Res. 37 (5): 417–25. PMID 11025405.
Béchard D, Scherpereel A, Hammad H, et al. (2001). "Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1.". J. Immunol. 167 (6): 3099–106. PMID 11544294.
Aitkenhead M, Wang SJ, Nakatsu MN, et al. (2002). "Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM.". Microvasc. Res. 63 (2): 159–71. doi:10.1006/mvre.2001.2380. PMID 11866539.
Tsai JC, Zhang J, Minami T, et al. (2002). "Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoter.". J. Vasc. Res. 39 (2): 148–59. PMID 12011586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wellner M, Herse F, Janke J, et al. (2004). "Endothelial cell specific molecule-1--a newly identified protein in adipocytes.". Horm. Metab. Res. 35 (4): 217–21. doi:10.1055/s-2003-39477. PMID 12778364.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Cong R, Jiang X, Wilson CM, et al. (2006). "Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1).". Biochem. Biophys. Res. Commun. 346 (2): 535–45. doi:10.1016/j.bbrc.2006.05.153. PMID 16764824.
Grigoriu BD, Depontieu F, Scherpereel A, et al. (2007). "Endocan expression and relationship with survival in human non-small cell lung cancer.". Clin. Cancer Res. 12 (15): 4575–82. doi:10.1158/1078-0432.CCR-06-0185. PMID 16899604.
Rennel E, Mellberg S, Dimberg A, et al. (2007). "Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer.". Exp. Cell Res. 313 (7): 1285–94. doi:10.1016/j.yexcr.2007.01.021. PMID 17362927.