ERGIC2

From Wikipedia, the free encyclopedia

ERGIC and golgi 2

Identifiers

ERGIC2; PTX1; CDA14; Erv41; MGC111152; cd002

External IDs

MGI: 1914706 HomoloGene: 6574

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• endoplasmic reticulum • ER-Golgi intermediate compartment • membrane • integral to membrane
Biological Process:	• transport • ER to Golgi vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016570 (mRNA)
NP_057654 (protein)

NM_026168 (mRNA)
NP_080444 (protein)

Location

Chr 12: 29.38 - 29.43 Mb

Chr 6: 148.14 - 148.17 Mb

Pubmed search

[1]

[2]

ERGIC and golgi 2, also known as ERGIC2, is a human gene located on human chromosome 12p11. It encodes a protein of 377 amino acid residues. The biological function of ERGIC2 protein is unknown, although it was initially identified as a candidate tumor suppressor of prostate cancer. It is now believed to be a chaperon molecule involved in protein trafficking between endoplasmic reticulum (ER) and Golgi. The protein contains two hydrophobic transmembrane domains that help anchoring the molecule on the ER membrane, such that its large luminal domain orients inside the ER lumen and both the N- and C-termini are facing the cytosol. ERGIC2 forms a complex with two other proteins, hErv46 and ERGIC32, resulting in a shuttle for protein trafficking between ER and Golgi.^[1]

[edit] References

^ Entrez Gene: ERGIC2 ERGIC and golgi 2.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Kwok SC, Liu X, Daskal I (2001). "Molecular cloning, expression, localization, and gene organization of PTX1, a human nuclear protein that is downregulated in prostate cancer.". DNA Cell Biol. 20 (6): 349-57. doi:10.1089/10445490152122460. PMID 11445006.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Liu X, Daskal I, Kwok SC (2003). "Effects of PTX1 expression on growth and tumorigenicity of the prostate cancer cell line PC-3.". DNA Cell Biol. 22 (7): 469-74. doi:10.1089/104454903322247343. PMID 12932305.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.". J. Biol. Chem. 279 (45): 47242-53. doi:10.1074/jbc.M406644200. PMID 15308636.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kwok SC, Liu X, Mangel P, Daskal I (2006). "PTX1(ERGIC2)-VP22 fusion protein upregulates interferon-beta in prostate cancer cell line PC-3.". DNA Cell Biol. 25 (9): 523-9. doi:10.1089/dna.2006.25.523. PMID 16989575.