ERCC1

From Wikipedia, the free encyclopedia

Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

PDB rendering based on 1z00.

Available structures: 1z00, 2a1i, 2a1j

Identifiers

Symbol(s)

ERCC1; UV20

External IDs

OMIM: 126380 MGI: 95412 HomoloGene: 1501

Gene ontology
Molecular Function:	• damaged DNA binding • endonuclease activity • hydrolase activity • sequence-specific DNA binding
Cellular Component:	• nucleotide-excision repair complex • intracellular • nucleus
Biological Process:	• DNA repair • nucleotide-excision repair

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001983 (mRNA)
NP_001974 (protein)

NM_007948 (mRNA)
NP_031974 (protein)

Location

Chr 19: 50.6 - 50.62 Mb

Chr 7: 18.5 - 18.52 Mb

Pubmed search

[1]

[2]

Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence), also known as ERCC1, is a human gene.

[edit] Further reading

Olaussen KA, Mountzios G, Soria JC (2007). "ERCC1 as a risk stratifier in platinum-based chemotherapy for nonsmall-cell lung cancer.". Current opinion in pulmonary medicine 13 (4): 284–9. doi:10.1097/MCP.0b013e32816b5c63. PMID 17534174.
van Duin M, de Wit J, Odijk H, et al. (1986). "Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10.". Cell 44 (6): 913–23. PMID 2420469.
van Duin M, van Den Tol J, Hoeijmakers JH, et al. (1989). "Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.". Mol. Cell. Biol. 9 (4): 1794–8. PMID 2471070.
Hoeijmakers JH (1987). "Characterization of genes and proteins involved in excision repair of human cells.". J. Cell Sci. Suppl. 6: 111–25. PMID 2821019.
Hoeijmakers JH, van Duin M, Westerveld A, et al. (1987). "Identification of DNA repair genes in the human genome.". Cold Spring Harb. Symp. Quant. Biol. 51 Pt 1: 91–101. PMID 3034490.
van Duin M, van den Tol J, Warmerdam P, et al. (1988). "Evolution and mutagenesis of the mammalian excision repair gene ERCC-1.". Nucleic Acids Res. 16 (12): 5305–22. PMID 3290851.
Westerveld A, Hoeijmakers JH, van Duin M, et al. (1984). "Molecular cloning of a human DNA repair gene.". Nature 310 (5976): 425–9. PMID 6462228.
Nagai A, Saijo M, Kuraoka I, et al. (1995). "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein.". Biochem. Biophys. Res. Commun. 211 (3): 960–6. PMID 7598728.
Li L, Elledge SJ, Peterson CA, et al. (1994). "Specific association between the human DNA repair proteins XPA and ERCC1.". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5012–6. PMID 8197174.
Park CH, Sancar A (1994). "Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins.". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5017–21. PMID 8197175.
McWhir J, Selfridge J, Harrison DJ, et al. (1994). "Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning.". Nat. Genet. 5 (3): 217–24. doi:10.1038/ng1193-217. PMID 8275084.
Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. PMID 8432525.
Yu JJ, Mu C, Lee KB, et al. (1997). "A nucleotide polymorphism in ERCC1 in human ovarian cancer cell lines and tumor tissues.". Mutat. Res. 382 (1-2): 13–20. PMID 9360634.
Hayashi T, Takao M, Tanaka K, Yasui A (1998). "ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines.". Mutat. Res. 407 (3): 269–76. PMID 9653453.
de Laat WL, Sijbers AM, Odijk H, et al. (1998). "Mapping of interaction domains between human repair proteins ERCC1 and XPF.". Nucleic Acids Res. 26 (18): 4146–52. PMID 9722633.
Lin YW, Kubota M, Koishi S, et al. (1998). "Analysis of mutations at the DNA repair genes in acute childhood leukaemia.". Br. J. Haematol. 103 (2): 462–6. PMID 9827920.
Houtsmuller AB, Rademakers S, Nigg AL, et al. (1999). "Action of DNA repair endonuclease ERCC1/XPF in living cells.". Science 284 (5416): 958–61. PMID 10320375.
Cheng L, Guan Y, Li L, et al. (1999). "Expression in normal human tissues of five nucleotide excision repair genes measured simultaneously by multiplex reverse transcription-polymerase chain reaction.". Cancer Epidemiol. Biomarkers Prev. 8 (9): 801–7. PMID 10498399.
Yu JJ, Thornton K, Guo Y, et al. (2002). "An ERCC1 splicing variant involving the 5'-UTR of the mRNA may have a transcriptional modulatory function.". Oncogene 20 (52): 7694–8. doi:10.1038/sj.onc.1204977. PMID 11753647.
Li QQ, Yunmbam MK, Zhong X, et al. (2002). "Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression.". Cell. Mol. Biol. (Noisy-le-grand) 47 Online Pub: OL61–72. PMID 11936875.