ERC2 (gene)

From Wikipedia, the free encyclopedia

ELKS/RAB6-interacting/CAST family member 2

Identifiers

ERC2; CAST; CAST1; ELKSL; KIAA0378; MGC133063; MGC133064; SPBC110; Spc110

External IDs

Gene ontology
Molecular Function:	• protein binding • PDZ domain binding
Cellular Component:	• endoplasmic reticulum • cytoskeleton • synaptosome • growth cone • presynaptic membrane • synapse
Biological Process:	• synaptogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015576 (mRNA)
NP_056391 (protein)

NM_177814 (mRNA)
NP_808482 (protein)

Location

Chr 3: 55.52 - 56.48 Mb

Chr 14: 26.45 - 27.31 Mb

Pubmed search

[1]

[2]

ELKS/RAB6-interacting/CAST family member 2, also known as ERC2, is a human gene.^[1]

[edit] References

^ Entrez Gene: ERC2 ELKS/RAB6-interacting/CAST family member 2.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. PMID 9205841.
Ohtsuka T, Takao-Rikitsu E, Inoue E, et al. (2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1.". J. Cell Biol. 158 (3): 577–90. doi:10.1083/jcb.200202083. PMID 12163476.
Wang Y, Liu X, Biederer T, Südhof TC (2002). "A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14464–9. doi:10.1073/pnas.182532999. PMID 12391317.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ko J, Na M, Kim S, et al. (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E, et al. (2004). "CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST.". Genes Cells 9 (1): 15–23. PMID 14723704.
Takao-Rikitsu E, Mochida S, Inoue E, et al. (2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.". J. Cell Biol. 164 (2): 301–11. doi:10.1083/jcb.200307101. PMID 14734538.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
tom Dieck S, Altrock WD, Kessels MM, et al. (2005). "Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex.". J. Cell Biol. 168 (5): 825–36. doi:10.1083/jcb.200408157. PMID 15728193.