Erbin (protein)
From Wikipedia, the free encyclopedia
Discovered in 1997, Erbin is a 200kDa protein containing a PDZ domain.[1] Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis in epidermal oncogenesis.[2] Erbin's N-terminal region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein.[3]
Erbin is named after its ability to bind ErbB2, though it shares a name with Saint Erbin, a 5th century Cornish monk. This has led some to suggest that Saint Erbin may be the patron saint of both PDZ domains and ErbB protein kinase receptors.
[edit] References
- ^ Borg JP, Marchetto S. et al. (2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor". Nat. Cell. Biol. 2 (7): 407–414. doi:. PMID 10878805.
- ^ Kolch, W. (2003). "Erbin: sorting out ErbB2 receptors or giving Ras a break?". Sci. STKE. 199: pe37. PMID 12966186.
- ^ Dai P, Xiong WC, and Mei L. (2006). "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex". J. Biol. Chem. 281 (2): 927–933. doi:. PMID 16301319.
