ERBB4

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V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
PDB rendering based on 2ahx.
Available structures: 2ahx
Identifiers
Symbol(s) ERBB4; HER4; MGC138404; p180erbB4
External IDs OMIM: 600543 MGI: 104771 HomoloGene: 21084
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2066 13869
Ensembl ENSG00000178568 ENSMUSG00000062209
Uniprot Q15303 O88459
Refseq NM_001042599 (mRNA)
NP_001036064 (protein)		 XM_001002143 (mRNA)
XP_001002143 (protein)
Location Chr 2: 211.96 - 213.11 Mb Chr 1: 67.97 - 69.04 Mb
Pubmed search [1] [2]

V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), also known as ERBB4, is a human gene.

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[1]

[edit] References

  1. ^ Entrez Gene: ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian).

[edit] Further reading

  • Carpenter G (2003). "ErbB-4: mechanism of action and biology.". Exp. Cell Res. 284 (1): 66–77. PMID 12648466. 
  • Culouscou JM, Plowman GD, Carlton GW, et al. (1993). "Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.". J. Biol. Chem. 268 (25): 18407–10. PMID 7689552. 
  • Zimonjic DB, Alimandi M, Miki T, et al. (1995). "Localization of the human HER4/erbB-4 gene to chromosome 2.". Oncogene 10 (6): 1235–7. PMID 7700649. 
  • Barbacci EG, Guarino BC, Stroh JG, et al. (1995). "The structural basis for the specificity of epidermal growth factor and heregulin binding.". J. Biol. Chem. 270 (16): 9585–9. PMID 7721889. 
  • Nagata K, Kohda D, Hatanaka H, et al. (1994). "Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.". EMBO J. 13 (15): 3517–23. PMID 8062828. 
  • Plowman GD, Culouscou JM, Whitney GS, et al. (1993). "Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.". Proc. Natl. Acad. Sci. U.S.A. 90 (5): 1746–50. PMID 8383326. 
  • Cohen BD, Green JM, Foy L, Fell HP (1996). "HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers.". J. Biol. Chem. 271 (9): 4813–8. PMID 8617750. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Elenius K, Paul S, Allison G, et al. (1997). "Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.". EMBO J. 16 (6): 1268–78. doi:10.1093/emboj/16.6.1268. PMID 9135143. 
  • Chang H, Riese DJ, Gilbert W, et al. (1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene.". Nature 387 (6632): 509–12. doi:10.1038/387509a0. PMID 9168114. 
  • Carraway KL, Weber JL, Unger MJ, et al. (1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.". Nature 387 (6632): 512–6. doi:10.1038/387512a0. PMID 9168115. 
  • Chow NH, Liu HS, Yang HB, et al. (1997). "Expression patterns of erbB receptor family in normal urothelium and transitional cell carcinoma. An immunohistochemical study.". Virchows Arch. 430 (6): 461–6. PMID 9230911. 
  • Zhang D, Sliwkowski MX, Mark M, et al. (1997). "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9562–7. PMID 9275162. 
  • Elenius K, Corfas G, Paul S, et al. (1997). "A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester.". J. Biol. Chem. 272 (42): 26761–8. PMID 9334263. 
  • Komurasaki T, Toyoda H, Uchida D, Morimoto S (1998). "Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.". Oncogene 15 (23): 2841–8. doi:10.1038/sj.onc.1201458. PMID 9419975. 
  • Fiddes RJ, Campbell DH, Janes PW, et al. (1998). "Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.". J. Biol. Chem. 273 (13): 7717–24. PMID 9516479. 
  • Jones JT, Ballinger MD, Pisacane PI, et al. (1998). "Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis.". J. Biol. Chem. 273 (19): 11667–74. PMID 9565587. 
  • Srinivasan R, Poulsom R, Hurst HC, Gullick WJ (1998). "Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.". J. Pathol. 185 (3): 236–45. doi:10.1002/(SICI)1096-9896(199807)185:3<236::AID-PATH118>3.0.CO;2-7. PMID 9771476. 
  • Harari D, Tzahar E, Romano J, et al. (1999). "Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase.". Oncogene 18 (17): 2681–9. doi:10.1038/sj.onc.1202631. PMID 10348342. 
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