Talk:Equine Exertional Rhabdomyolysis
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This is brand new, 2007 Morris Animal Foundation research and needs to be added into the article in a way that is not a copyio:
Hereditary Disorders
"Mapping the Recurrent Exertional Rhabdomyolysis Gene in Thoroughbred Horses"
University of Minnesota, James R. Mickelson, PhD
Completed: October 2007
Description:
A recurrent form of the heritable muscle disorder, tying-up is common in thoroughbred horses. Also called recurrent exertional rhabdomyolysis (RER), this condition causes painful cramping and muscle damage that occurs after mild to moderate exercise. Although related muscle disorders exist in other species, RER in thoroughbreds appears to be a novel genetic defect. The investigators in this study seek to locate the chromosomal position of the RER gene. Identifying a DNA marker closely associated with the RER gene would allow them to identify the precise genetic alteration that causes tying-up, predict which horses are susceptible and develop specific therapies and treatments for horses affected by this disorder.
Results:
Researchers determined that susceptibility to RER is highly heritable in thoroughbred horses and is likely a novel muscle disease that affects the regulation of muscle contraction. Although the specific RER gene and the mutation that causes that disease have not yet been identified, when its location is found, it will allow for a more accurate diagnosis of RER susceptibility. Through this study, researchers learned a great deal about how to design and implement genetic mapping studies in horses, and this knowledge has allowed them to take the leadership role in Morris Animal Foundation's Equine Consortium for Genetic Research. They feel RER will be one of the first diseases mapped using the SNP chip technology that is being developed through the consortium.
Source: http://www.thehorse.com/ViewArticle.aspx?ID=10990
—Preceding unsigned comment added by 161.7.2.160 (talk) 20:32, 18 December 2007 (UTC)
[edit] Equine Exertional Rhabdomyolysis is not just one disease
This article is outdated in the belief that there is one common rhabdomyolysis. Here's an excerpt from the Merck veterinary manual (fetched on April 5, 2008):
"Although exertional rhabdomyolysis was previously considered a single disease described as azoturia, tying-up, or cording up, it is now known to comprise several different myopathies, which, despite similarities in clinical presentation, differ significantly in etiopathology."
http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/91006.htm
This new information about the different categories of rhabdomyolysis needs to be added to this article and the title of the article changed to exhibit this change in the latest knowledge about exertional myopathies in horses.
