EPS8

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Epidermal growth factor receptor pathway substrate 8
PDB rendering based on 1aoj.
Available structures: 1aoj, 1i07, 1i0c
Identifiers
Symbol(s) EPS8;
External IDs OMIM: 600206 MGI: 104684 HomoloGene: 3272
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2059 13860
Ensembl ENSG00000151491 ENSMUSG00000015766
Uniprot Q12929 Q3TM41
Refseq NM_004447 (mRNA)
NP_004438 (protein)		 NM_007945 (mRNA)
NP_031971 (protein)
Location Chr 12: 15.66 - 15.83 Mb Chr 6: 137.44 - 137.61 Mb
Pubmed search [1] [2]

Epidermal growth factor receptor pathway substrate 8, also known as EPS8, is a human gene.[1]

This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[1]

[edit] References

  1. ^ a b Entrez Gene: EPS8 epidermal growth factor receptor pathway substrate 8.

[edit] Further reading

  • Di Fiore PP, Scita G (2002). "Eps8 in the midst of GTPases.". Int. J. Biochem. Cell Biol. 34 (10): 1178-83. PMID 12127568. 
  • Cardwell C (1977). "Student or worker? International Meeting of Student Nurses (European Group).". Nursing mirror and midwives journal 143 (19): 38. PMID 1049958. 
  • Castagnino P, Biesova Z, Wong WT, et al. (1995). "Direct binding of eps8 to the juxtamembrane domain of EGFR is phosphotyrosine- and SH2-independent.". Oncogene 10 (4): 723-9. PMID 7532293. 
  • Karlsson T, Songyang Z, Landgren E, et al. (1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.". Oncogene 10 (8): 1475-83. PMID 7537362. 
  • Avantaggiato V, Torino A, Wong WT, et al. (1995). "Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse development.". Oncogene 11 (6): 1191-8. PMID 7566980. 
  • Matoskova B, Wong WT, Salcini AE, et al. (1995). "Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation.". Mol. Cell. Biol. 15 (7): 3805-12. PMID 7791787. 
  • Wong WT, Carlomagno F, Druck T, et al. (1994). "Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24.". Oncogene 9 (10): 3057-61. PMID 8084614. 
  • Fazioli F, Minichiello L, Matoska V, et al. (1993). "Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals.". EMBO J. 12 (10): 3799-808. PMID 8404850. 
  • Matòsková B, Wong WT, Seki N, et al. (1996). "RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain.". Oncogene 12 (12): 2563-71. PMID 8700515. 
  • Matòsková B, Wong WT, Nomura N, et al. (1996). "RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy-terminal truncation.". Oncogene 12 (12): 2679-88. PMID 8700527. 
  • Biesova Z, Piccoli C, Wong WT (1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth.". Oncogene 14 (2): 233-41. doi:10.1038/sj.onc.1200822. PMID 9010225. 
  • Kishan KV, Scita G, Wong WT, et al. (1997). "The SH3 domain of Eps8 exists as a novel intertwined dimer.". Nat. Struct. Biol. 4 (9): 739-43. PMID 9303002. 
  • Maa MC, Lai JR, Lin RW, Leu TH (1999). "Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src.". Biochim. Biophys. Acta 1450 (3): 341-51. PMID 10395945. 
  • Scita G, Nordstrom J, Carbone R, et al. (1999). "EPS8 and E3B1 transduce signals from Ras to Rac.". Nature 401 (6750): 290-3. doi:10.1038/45822. PMID 10499589. 
  • Inobe M, Katsube K, Miyagoe Y, et al. (2000). "Identification of EPS8 as a Dvl1-associated molecule.". Biochem. Biophys. Res. Commun. 266 (1): 216-21. doi:10.1006/bbrc.1999.1782. PMID 10581192. 
  • Lanzetti L, Rybin V, Malabarba MG, et al. (2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.". Nature 408 (6810): 374-7. doi:10.1038/35042605. PMID 11099046. 
  • Ion A, Crosby AH, Kremer H, et al. (2000). "Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6.". J. Med. Genet. 37 (11): 884-6. PMID 11185075. 
  • Scita G, Tenca P, Areces LB, et al. (2001). "An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.". J. Cell Biol. 154 (5): 1031-44. doi:10.1083/jcb.200103146. PMID 11524436. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
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