Epoxyeicosatrienoic acid

From Wikipedia, the free encyclopedia

The Epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid. These nonclassic eicosanoids act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.^[1]

[edit] Biological effects

EETs are cardioprotective after ischemic heart attack and reperfusion.^[2] They act in the corpus cavernosum to maintain penile erection.^[3] Specific epoxidation of EET sites produces endogenous PPARα agonists.^[4]

[edit] References

1. ^  Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ.. Epoxyeicosatrienoic acids (EETs) in cardioprotection: Ischemic versus reperfusion injury.. Am J Physiol Heart Circ Physiol. date=2006 Feb 10. Retrieved on 2006-03-11.
2. ^  Jin L, Foss CE, Zhao X, Mills TM, Wang MH, McCluskey LP, Yaddanapud GS, Falck JR, Imig JD, Webb RC. (2006 Jan 13.). Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.. FASEB J. 2006 Mar;20(3):539-41.. Retrieved on 2006-03-11.PubMed cite.
3. ^ Spector AA,Fang X, Snyder GD, Weintraub NL (Jan 2004). "Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function". Prog Lipid Res 43 (1): 55–90. doi:10.1016/S0163-7827(03)00049-3. PMID 14636671. 
4. ^ Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL (Jul 2007). "Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha". Drug Metab Dispos 37 (7): 1126–1134. doi:10.1124/dmd.106.013839. PMID 17431031.