Ephrin A1

From Wikipedia, the free encyclopedia

Ephrin-A1

Identifiers

EFNA1; B61; ECKLG; EFL1; EPLG1; LERK1; TNFAIP4

External IDs

OMIM: 191164 MGI: 103236 HomoloGene: 3262

Gene ontology
Molecular Function:	• ephrin receptor binding • GPI anchor binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• activation of MAPK activity • cell-cell signaling • neuron differentiation • ephrin receptor signaling pathway • regulation of axonogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004428 (mRNA)
NP_004419 (protein)

NM_010107 (mRNA)
NP_034237 (protein)

Location

Chr 1: 153.37 - 153.37 Mb

Chr 3: 89.36 - 89.37 Mb

Pubmed search

[1]

[2]

Ephrin-A1, also known as EFNA1, is a human gene.^[1]

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.^[1]

[edit] References

^ ^a ^b Entrez Gene: EFNA1 ephrin-A1.

[edit] Further reading

Pandey A, Lindberg RA, Dixit VM (1996). "Cell signalling. Receptor orphans find a family.". Curr. Biol. 5 (9): 986–9. PMID 8542290.
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
Holzman LB, Marks RM, Dixit VM (1990). "A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein.". Mol. Cell. Biol. 10 (11): 5830–8. PMID 2233719.
Mahadevan D, Thanki N, Singh J, et al. (1995). "Structural studies on the PH domains of Db1, Sos1, IRS-1, and beta ARK1 and their differential binding to G beta gamma subunits.". Biochemistry 34 (28): 9111–7. PMID 7619809.
Kozlosky CJ, Maraskovsky E, McGrew JT, et al. (1995). "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.". Oncogene 10 (2): 299–306. PMID 7838529.
Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.". Science 266 (5186): 816–9. PMID 7973638.
Beckmann MP, Cerretti DP, Baum P, et al. (1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.". EMBO J. 13 (16): 3757–62. PMID 8070404.
Cerretti DP, Lyman SD, Kozlosky CJ, et al. (1997). "The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3.". Genomics 33 (2): 277–82. doi:10.1006/geno.1996.0192. PMID 8660976.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. PMID 8755474.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403–4. PMID 9267020.
Nagel W, Schilcher P, Zeitlmann L, Kolanus W (1998). "The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function.". Mol. Biol. Cell 9 (8): 1981–94. PMID 9693361.