Ephedrine dehydrogenase

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In enzymology, an ephedrine dehydrogenase (EC 1.5.1.18) is an enzyme that catalyzes the chemical reaction

(-)-ephedrine + NAD⁺ (R)-2-methylimino-1-phenylpropan-1-ol + NADH + H⁺

Thus, the two substrates of this enzyme are (-)-ephedrine and NAD⁺, whereas its 3 products are (R)-2-methylimino-1-phenylpropan-1-ol, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (-)-ephedrine:NAD+ 2-oxidoreductase.

[edit] References

• IUBMB entry for 1.5.1.18
• BRENDA references for 1.5.1.18 (Recommended.)
• PubMed references for 1.5.1.18
• PubMed Central references for 1.5.1.18
• Google Scholar references for 1.5.1.18
• Klamann E, Lingens F (1980). "Degradation of (-)-ephedrine by Pseudomonas putida. Detection of (-)-ephedrine: NAD+-oxidoreductase from Arthrobacter globiformis". Z. Naturforsch. [C]. 35: 80–7. PMID 7405363. 

[edit] External links

The CAS registry number for this enzyme class is 73508-06-2.

• IUBMB entry for 1.5.1.18

• KEGG entry for 1.5.1.18

• BRENDA entry for 1.5.1.18

• NiceZyme view of 1.5.1.18

• EC2PDB: PDB structures for 1.5.1.18

• PRIAM entry for 1.5.1.18

• PUMA2 entry for 1.5.1.18

• IntEnz: Integrated Enzyme entry for 1.5.1.18

• MetaCyc entry for 1.5.1.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047877: ephedrine dehydrogenase

• AMIGO entry for GO code 0047877: ephedrine dehydrogenase