EPH receptor B2

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EPH receptor B2
PDB rendering based on 1b4f.
Available structures: 1b4f, 1f0m, 1jpa, 1kgy, 1nuk, 1sgg, 1shw, 2hen
Identifiers
Symbol(s)	EPHB2; CAPB; DRT; EPHT3; ERK; Hek5; MGC87492; PCBC; Tyro5
External IDs	OMIM: 600997 MGI: 99611 HomoloGene: 37925
Gene ontology Molecular Function: • nucleotide binding • protein-tyrosine kinase activity • receptor activity • ephrin receptor activity • transmembrane-ephrin receptor activity • receptor binding • ATP binding • axon guidance receptor activity • transferase activity Cellular Component: • membrane • integral to membrane • synapse Biological Process: • protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development • axon guidance • learning • organ morphogenesis • regulation of neuronal synaptic plasticity • positive regulation of long-term neuronal synaptic plasticity • regulation of axonogenesis
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2048	13844
Ensembl	ENSG00000133216	ENSMUSG00000028664
Uniprot	P29323	Q6GTQ7
Refseq	NM_004442 (mRNA) NP_004433 (protein)	NM_010142 (mRNA) NP_034272 (protein)
Location	Chr 1: 22.91 - 23.11 Mb	Chr 4: 135.93 - 136.11 Mb
Pubmed search	[1]	[2]

EPH receptor B2, also known as EPHB2, is a human gene.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[1]

[edit] References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Transmembrane receptor, tyrosine kinase: receptor tyrosine kinases (EC 2.7.10.1) I EGF (HER2/neu, Her 3, Her 4) II Insulin - IGF-1 III Platelet-derived growth factor IV Fibroblast growth factor (FGFR1, FGFR2, FGFR3) V VEGF receptors - Flk-1 - Flt-1 VII TRK: TrkA - TrkB - TrkC other VIII: Eph (B2) - XI: Angiopoietin Receptors: Tie-1 & Tie-2 - XIV: RET - XVI: Related to receptor tyrosine kinase - XVII: MuSK