EPH receptor B1

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EPH receptor B1
PDB rendering based on 2djs.
Available structures: 2djs
Identifiers
Symbol(s) EPHB1; NET; ELK; EPHT2; FLJ37986; Hek6
External IDs OMIM: 600600 MGI: 1096337 HomoloGene: 20936
Orthologs
Human Mouse
Entrez 2047 270190
Ensembl n/a ENSMUSG00000032537
Uniprot n/a Q8CA63
Refseq NM_004441 (mRNA)
NP_004432 (protein)		 NM_173447 (mRNA)
NP_775623 (protein)
Location n/a Chr 9: 101.78 - 102.08 Mb
Pubmed search [1] [2]

EPH receptor B1, also known as EPHB1, is a human gene.[1]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[1]

[edit] References

  1. ^ a b Entrez Gene: EPHB1 EPH receptor B1.

[edit] Further reading

  • Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
  • Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626. 
  • Abrahamson DR, Robert B, Hyink DP, et al. (1998). "Origins and formation of microvasculature in the developing kidney.". Kidney Int. Suppl. 67: S7–11. PMID 9736245. 
  • Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129. 
  • Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216. 
  • Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993. 
  • Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076. 
  • Larose L, Gish G, Shoelson S, Pawson T (1993). "Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1.". Oncogene 8 (9): 2493–9. PMID 7689724. 
  • Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.". Science 266 (5186): 816–9. PMID 7973638. 
  • Beckmann MP, Cerretti DP, Baum P, et al. (1994). "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.". EMBO J. 13 (16): 3757–62. PMID 8070404. 
  • Cerretti DP, Vanden Bos T, Nelson N, et al. (1996). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases.". Mol. Immunol. 32 (16): 1197–205. PMID 8559144. 
  • Tang XX, Biegel JA, Nycum LM, et al. (1996). "cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain.". Genomics 29 (2): 426–37. doi:10.1006/geno.1995.9985. PMID 8666391. 
  • Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. PMID 8755474. 
  • Stein E, Cerretti DP, Daniel TO (1996). "Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.". J. Biol. Chem. 271 (38): 23588–93. PMID 8798570. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Kozlosky CJ, VandenBos T, Park L, et al. (1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.". Cytokine 9 (8): 540–9. doi:10.1006/cyto.1997.0199. PMID 9245480. 
  • "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403–4. PMID 9267020. 
  • Stein E, Huynh-Do U, Lane AA, et al. (1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.". J. Biol. Chem. 273 (3): 1303–8. PMID 9430661. 
  • Stein E, Lane AA, Cerretti DP, et al. (1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.". Genes Dev. 12 (5): 667–78. PMID 9499402. 
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