EPHB3

From Wikipedia, the free encyclopedia

EPH receptor B3

Identifiers

EPHB3; ETK2; HEK2; TYRO6

External IDs

OMIM: 601839 MGI: 104770 HomoloGene: 20938

Gene ontology
Molecular Function:	• nucleotide binding • receptor activity • ephrin receptor activity • ATP binding • axon guidance receptor activity • transferase activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• protein amino acid phosphorylation • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • axon guidance

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004443 (mRNA)
NP_004434 (protein)

NM_010143 (mRNA)
NP_034273 (protein)

Location

Chr 3: 185.76 - 185.78 Mb

Chr 16: 21.12 - 21.14 Mb

Pubmed search

[1]

[2]

EPH receptor B3, also known as EPHB3, is a human gene.^[1]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.^[1]

[edit] References

^ ^a ^b Entrez Gene: EPHB3 EPH receptor B3.

[edit] Further reading

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309-45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151-81. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033-44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177-244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993-1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155-64. PMID 11256076.
Böhme B, Holtrich U, Wolf G, et al. (1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2.". Oncogene 8 (10): 2857-62. PMID 8397371.
Böhme B, VandenBos T, Cerretti DP, et al. (1996). "Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.". J. Biol. Chem. 271 (40): 24747-52. PMID 8798744.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403-4. PMID 9267020.
Bergemann AD, Zhang L, Chiang MK, et al. (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube.". Oncogene 16 (4): 471-80. doi:10.1038/sj.onc.1201557. PMID 9484836.
Hock B, Böhme B, Karn T, et al. (1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.". Oncogene 17 (2): 255-60. doi:10.1038/sj.onc.1201907. PMID 9674711.
Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779-84. PMID 9707552.
Ciossek T, Monschau B, Kremoser C, et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.". Eur. J. Neurosci. 10 (5): 1574-80. PMID 9751130.
Adams RH, Wilkinson GA, Weiss C, et al. (1999). "Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.". Genes Dev. 13 (3): 295-306. PMID 9990854.