EPHA8

From Wikipedia, the free encyclopedia

EPH receptor A8

PDB rendering based on 1ucv.

Available structures: 1ucv, 1x5l

Identifiers

Symbol(s)

EPHA8; EEK; HEK3; KIAA1459

External IDs

OMIM: 176945 MGI: 109378 HomoloGene: 22436

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • receptor activity • ephrin receptor activity • ATP binding • transferase activity
Cellular Component:	• plasma membrane • membrane • integral to membrane
Biological Process:	• protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway

Orthologs

Human

Mouse

Refseq

NM_001006943 (mRNA)
NP_001006944 (protein)

NM_007939 (mRNA)
NP_031965 (protein)

Location

Chr 1: 22.76 - 22.8 Mb

Chr 4: 136.2 - 136.23 Mb

Pubmed search

[1]

[2]

EPH receptor A8, also known as EPHA8, is a human gene.^[1]

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.^[1]

[edit] References

^ ^a ^b Entrez Gene: EPHA8 EPH receptor A8.

[edit] Further reading

Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Holland SJ, Peles E, Pawson T, Schlessinger J (1998). "Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta.". Curr. Opin. Neurobiol. 8 (1): 117–27. PMID 9568399.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance.". Curr. Biol. 14 (3): R121–3. PMID 14986683.
Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain.". Curr. Opin. Neurobiol. 14 (3): 288–96. doi:10.1016/j.conb.2004.04.003. PMID 15194108.
Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function.". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 10 (4): 304–14. doi:10.1177/1073858403262221. PMID 15271258.
Chan J, Watt VM (1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases.". Oncogene 6 (6): 1057–61. PMID 1648701.
Park S, Sánchez MP (1997). "The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands.". Oncogene 14 (5): 533–42. doi:10.1038/sj.onc.1200857. PMID 9053851.
Park S, Frisén J, Barbacid M (1997). "Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.". EMBO J. 16 (11): 3106–14. doi:10.1093/emboj/16.11.3106. PMID 9214628.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403–4. PMID 9267020.
Lemke G (1998). "A coherent nomenclature for Eph receptors and their ligands.". Mol. Cell. Neurosci. 9 (5-6): 331–2. doi:10.1006/mcne.1997.0630. PMID 9361271.
Choi S, Park S (1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.". Oncogene 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895.