EPHA7
From Wikipedia, the free encyclopedia
EPH receptor A7
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Identifiers | ||||||||||||||
Symbol(s) | EPHA7; EHK3; HEK11 | |||||||||||||
External IDs | OMIM: 602190 MGI: 95276 HomoloGene: 20935 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 2045 | 13841 | ||||||||||||
Ensembl | ENSG00000135333 | ENSMUSG00000028289 | ||||||||||||
Uniprot | Q15375 | Q3V3T7 | ||||||||||||
Refseq | NM_004440 (mRNA) NP_004431 (protein) |
NM_010141 (mRNA) NP_034271 (protein) |
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Location | Chr 6: 94.01 - 94.19 Mb | Chr 4: 28.98 - 29.13 Mb | ||||||||||||
Pubmed search | [1] | [2] |
EPH receptor A7, also known as EPHA7, is a human gene.[1]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.[1]
[edit] References
[edit] Further reading
- Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi: . PMID 9530499.
- Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
- Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi: . PMID 11128993.
- Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
- Fox GM, Holst PL, Chute HT, et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.". Oncogene 10 (5): 897–905. PMID 7898931.
- Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. PMID 8755474.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
- Ciossek T, Ullrich A (1997). "Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1.". Oncogene 14 (1): 35–43. doi: . PMID 9010230.
- "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403–4. PMID 9267020.
- Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. PMID 9707552.
- Bianchi LM, Liu H (1999). "Comparison of ephrin-A ligand and EphA receptor distribution in the developing inner ear.". Anat. Rec. 254 (1): 127–34. PMID 9892426.
- Janis LS, Cassidy RM, Kromer LF (1999). "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum.". J. Neurosci. 19 (12): 4962–71. PMID 10366629.
- Stubbs J, Palmer A, Vidovic M, Marotte LR (2000). "Graded expression of EphA3 in the retina and ephrin-A2 in the superior colliculus during initial development of coarse topography in the wallaby retinocollicular projection.". Eur. J. Neurosci. 12 (10): 3626–36. PMID 11029633.