EPHA5

From Wikipedia, the free encyclopedia

EPH receptor A5

Identifiers

EPHA5; TYRO4; CEK7; EHK1; HEK7

External IDs

OMIM: 600004 MGI: 99654 HomoloGene: 55824

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • receptor activity • transmembrane-ephrin receptor activity • ATP binding • transferase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• protein amino acid phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004439 (mRNA)
NP_004430 (protein)

NM_007937 (mRNA)
NP_031963 (protein)

Location

Chr 4: 65.87 - 66.22 Mb

Chr 5: 85.13 - 85.49 Mb

Pubmed search

[1]

[2]

EPH receptor A5, also known as EPHA5, is a human gene.^[1]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.^[1]

[edit] References

^ ^a ^b Entrez Gene: EPHA5 EPH receptor A5.

[edit] Further reading

Zhou R (1997). "Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands.". Cell Tissue Res. 290 (2): 251–9. PMID 9321686.
Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1.". Cell Tissue Res. 290 (2): 261–4. PMID 9321687.
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177–244. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076.
Spritz RA, Strunk KM, Lee ST, et al. (1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12.". Genomics 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.
Fox GM, Holst PL, Chute HT, et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.". Oncogene 10 (5): 897–905. PMID 7898931.
Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.". Science 266 (5186): 816–9. PMID 7973638.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron 17 (1): 9–19. PMID 8755474.
Miescher GC, Taylor V, Olivieri G, et al. (1997). "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors.". Brain Res. Mol. Brain Res. 46 (1-2): 17–24. PMID 9191074.
"Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee." (1997). Cell 90 (3): 403–4. PMID 9267020.
Stein E, Savaskan NE, Ninnemann O, et al. (1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting.". J. Neurosci. 19 (20): 8885–93. PMID 10516308.