EPB49

From Wikipedia, the free encyclopedia

Erythrocyte membrane protein band 4.9 (dematin)

PDB rendering based on 1qzp.

Available structures: 1qzp, 1zv6

Identifiers

Symbol(s)

EPB49; DEMATIN; DMT

External IDs

OMIM: 125305 MGI: 99670 HomoloGene: 1496

Gene ontology
Molecular Function:	• actin binding
Cellular Component:	• actin cytoskeleton
Biological Process:	• cytoskeleton organization and biogenesis • barbed-end actin filament capping • actin filament bundle formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001978 (mRNA)
NP_001969 (protein)

NM_013514 (mRNA)
NP_038542 (protein)

Location

Chr 8: 21.97 - 22 Mb

Chr 14: 69.34 - 69.37 Mb

Pubmed search

[1]

[2]

Erythrocyte membrane protein band 4.9 (dematin), also known as EPB49, is a human gene.^[1]

[edit] References

^ Entrez Gene: EPB49 erythrocyte membrane protein band 4.9 (dematin).

[edit] Further reading

Azim AC, Knoll JH, Beggs AH, Chishti AH (1995). "Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily.". J. Biol. Chem. 270 (29): 17407-13. PMID 7615546.
Rana AP, Ruff P, Maalouf GJ, et al. (1993). "Cloning of human erythroid dematin reveals another member of the villin family.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6651-5. PMID 8341682.
Azim AC, Marfatia SM, Korsgren C, et al. (1996). "Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins.". Biochemistry 35 (9): 3001-6. doi:10.1021/bi951745y. PMID 8608138.
Khanna R, Chang SH, Andrabi S, et al. (2002). "Headpiece domain of dematin is required for the stability of the erythrocyte membrane.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6637-42. doi:10.1073/pnas.052155999. PMID 12011427.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function.". Biochem. Biophys. Res. Commun. 311 (4): 1019-25. PMID 14623284.
Frank BS, Vardar D, Chishti AH, McKnight CJ (2004). "The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site.". J. Biol. Chem. 279 (9): 7909-16. doi:10.1074/jbc.M310524200. PMID 14660664.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Vermeulen W, Van Troys M, Bourry D, et al. (2006). "Identification of the PXW sequence as a structural gatekeeper of the headpiece C-terminal subdomain fold.". J. Mol. Biol. 359 (5): 1277-92. doi:10.1016/j.jmb.2006.04.042. PMID 16697408.