EPB41L3

From Wikipedia, the free encyclopedia

Erythrocyte membrane protein band 4.1-like 3

PDB rendering based on 2he7.

Available structures: 2he7

Identifiers

Symbol(s)

EPB41L3; 4.1B; DAL-1; DAL1; FLJ37633; KIAA0987

External IDs

OMIM: 605331 MGI: 103008 HomoloGene: 49308

Gene ontology
Molecular Function:	• actin binding • structural molecule activity • binding
Cellular Component:	• cytoplasm • cytoskeleton • plasma membrane • intercellular junction
Biological Process:	• biological_process • cortical actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012307 (mRNA)
NP_036439 (protein)

NM_013813 (mRNA)
NP_038841 (protein)

Location

Chr 18: 5.38 - 5.53 Mb

Chr 17: 69.06 - 69.19 Mb

Pubmed search

[1]

[2]

Erythrocyte membrane protein band 4.1-like 3, also known as EPB41L3, is a human gene.^[1]

[edit] References

^ Entrez Gene: EPB41L3 erythrocyte membrane protein band 4.1-like 3.

[edit] Further reading

Calinisan V, Gravem D, Chen RP, et al. (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.". Front. Biosci. 11: 1646–66. PMID 16368544.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Adams MD, Soares MB, Kerlavage AR, et al. (1993). "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library.". Nat. Genet. 4 (4): 373–80. doi:10.1038/ng0893-373. PMID 8401585.
Peters LL, Weier HU, Walensky LD, et al. (1999). "Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.". Genomics 54 (2): 348–50. doi:10.1006/geno.1998.5537. PMID 9828140.
Tran YK, Bögler O, Gorse KM, et al. (1999). "A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer.". Cancer Res. 59 (1): 35–43. PMID 9892180.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032.
Gutmann DH, Donahoe J, Perry A, et al. (2000). "Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas.". Hum. Mol. Genet. 9 (10): 1495–500. PMID 10888600.
Yu T, Robb VA, Singh V, et al. (2002). "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins.". Biochem. J. 365 (Pt 3): 783–9. doi:10.1042/BJ20020060. PMID 11996670.
Charboneau AL, Singh V, Yu T, Newsham IF (2002). "Suppression of growth and increased cellular attachment after expression of DAL-1 in MCF-7 breast cancer cells.". Int. J. Cancer 100 (2): 181–8. doi:10.1002/ijc.10470. PMID 12115567.
Yageta M, Kuramochi M, Masuda M, et al. (2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer.". Cancer Res. 62 (18): 5129–33. PMID 12234973.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Heinrich B, Hartmann C, Stemmer-Rachamimov AO, et al. (2003). "Multiple meningiomas: Investigating the molecular basis of sporadic and familial forms.". Int. J. Cancer 103 (4): 483–8. doi:10.1002/ijc.10840. PMID 12478663.
Denisenko-Nehrbass N, Oguievetskaia K, Goutebroze L, et al. (2003). "Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres.". Eur. J. Neurosci. 17 (2): 411–6. PMID 12542678.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Robb VA, Li W, Gutmann DH (2004). "Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression.". Oncogene 23 (20): 3589–96. doi:10.1038/sj.onc.1207445. PMID 15116094.
Kittiniyom K, Mastronardi M, Roemer M, et al. (2004). "Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation.". Genes Chromosomes Cancer 40 (3): 190–203. doi:10.1002/gcc.20034. PMID 15138999.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Singh V, Miranda TB, Jiang W, et al. (2004). "DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.". Oncogene 23 (47): 7761–71. doi:10.1038/sj.onc.1208057. PMID 15334060.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.