Eosinophilia
From Wikipedia, the free encyclopedia
| Eosinophilia Classification and external resources |
|
| ICD-10 | D72.1 |
|---|---|
| ICD-9 | 288.3 |
| DiseasesDB | 4328 |
| eMedicine | med/685 |
| MeSH | D004802 |
Eosinophilia is the state of having a high concentration of eosinophils (eosinophil granulocytes) in the blood. The normal concentration is between 0 and 0.5 x 109 eosinophils per litre of blood. Eosinophilia can be reactive (in response to other stimuli such as allergy or infection) or non reactive.
The release of interleukin 5 by T cells, mast cells and macrophages stimulates the production of eosinophils.
[edit] Causes
Diseases that feature eosinophilia:
- Hypereosinophilic syndrome
- Parasitic infections (intestinal helminthiasis)
- Allergic disorders
- Some drug reactions
- Cholesterol embolization
- Churg-Strauss syndrome
- Some forms of chronic myeloid leukaemia
- Hodgkin's disease
- Gleich's syndrome
- Addison's disease
- Clonorchis sinensis, a type of flatworm
[edit] Management
If eosinophilia persists for six months, and all major recognized secondary causes have been excluded (parasitic/helminthic infections, HIV, drug hypersensitivity, cancer, lymphomas, and primary allergic disorders), the diagnosis of idiopathic eosinophilia is made. It is modified to hypereosinophilic syndrome if there is evidence of organ involvement.[1]
