Enzyme-thiol transhydrogenase (glutathione-disulfide)
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In enzymology, an enzyme-thiol transhydrogenase (glutathione-disulfide) (EC 1.8.4.7) is an enzyme that catalyzes the chemical reaction
- [xanthine dehydrogenase] + glutathione disulfide
[xanthine oxidase] + 2 glutathione
Thus, the two substrates of this enzyme are [[[xanthine dehydrogenase]]] and glutathione disulfide, whereas its two products are [[[xanthine oxidase]]] and glutathione.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is [xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase. Other names in common use include [xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase, enzyme-thiol transhydrogenase (oxidized-glutathione), glutathione-dependent thiol:disulfide oxidoreductase, and thiol:disulfide oxidoreductase. This enzyme participates in glutathione metabolism.
[edit] References
- IUBMB entry for 1.8.4.7
- BRENDA references for 1.8.4.7 (Recommended.)
- PubMed references for 1.8.4.7
- PubMed Central references for 1.8.4.7
- Google Scholar references for 1.8.4.7
- Battelli MG, Lorenzoni E (1982). "Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver". Biochem. J. 207: 133–8. PMID 6960894.
[edit] External links
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- The CAS registry number for this enzyme class is 85030-79-1.
[edit] Gene Ontology (GO) codes
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