Entner-Doudoroff Pathway

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The Entner-Doudoroff pathway describes an alternate series of reactions that catabolize glucose to pyruvate using a set of enzymes different from those used in either glycolysis or the pentose phosphate pathway. Most bacteria use glycolysis and the pentose phosphate pathway.

Distinct features of the Entner-Doudoroff pathway are that it:

• Occurs only in prokaryotes.

• Uses 6-phosphogluconate dehydrase and 2-keto-3-deoxyglucosephophate aldolase to create pyruvates from glucose.

• Does not produce gases during its metabolic process, distinguishing them from microorganisms of enteric species.

• Has a net yield of 1 ATP for every glucose molecule processed, as well as 1 NADH and 1 NADPH. By comparison, glycolysis has a net yield of 2 ATP and 2 NADH for every one glucose molecule processed.

[edit] Organisms that the Utilize Entner-Doudoroff Pathway

There are a few bacteria that substitute classic glycolysis with the Entner-Doudoroff Pathway. They may lack enzymes essential for glycolysis, such as phosphofructokinase-1. Most organisms that use the pathway are aerobes due to the low ATP yield per glucose. ^[1]

• Pseudomonas aeruginosa, a Gram-negative bacteria
• Azotobacter, a Gram-negative bacteria
• Rhizobium, a Gram-negative bacteria
• Enterococcus faecalis, a Gram-positive bacteria
• Zymomonas mobilis, an anaerobic organism

[edit] References

Mohamed, M. Optometry Professor. Smith, K. Optometrist. Sohn, S. Biomedical Science Professor.

1. ^ Zymomonas mobilis

[edit] External links

• Diagram at umt.edu