Ent-kaurene synthase

From Wikipedia, the free encyclopedia

In enzymology, an ent-kaurene synthase (EC 4.2.3.19) is an enzyme that catalyzes the chemical reaction

ent-copalyl diphosphate $\rightleftharpoons$ ent-kaurene + diphosphate

Hence, this enzyme has one substrate, ent-copalyl diphosphate, and two products, ent-kaurene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming). Other names in common use include ent-kaurene synthase B, ent-kaurene synthetase B, ent-copalyl-diphosphate diphosphate-lyase, and (cyclizing). This enzyme participates in diterpenoid biosynthesis.

[edit] References

IUBMB entry for 4.2.3.19
BRENDA references for 4.2.3.19 (Recommended.)
PubMed references for 4.2.3.19
PubMed Central references for 4.2.3.19
Google Scholar references for 4.2.3.19
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W, Sassa T (2000). "Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase". Biosci. Biotechnol. Biochem. 64: 660–4. doi:10.1271/bbb.64.660. PMID 10803977.