ENTPD6

From Wikipedia, the free encyclopedia

Ectonucleoside triphosphate diphosphohydrolase 6 (putative function)

Identifiers

ENTPD6; CD39L2; DKFZp781G2277; DKFZp781K21102; FLJ36711; IL-6SAG; IL6ST2; NTPDase-6; dJ738P15.3

External IDs

OMIM: 603160 MGI: 1202295 HomoloGene: 68170

Gene ontology
Molecular Function:	• magnesium ion binding • calcium ion binding • hydrolase activity • nucleoside-diphosphatase activity
Cellular Component:	• membrane • integral to membrane

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001247 (mRNA)
NP_001238 (protein)

NM_172117 (mRNA)
NP_742115 (protein)

Location

Chr 20: 25.12 - 25.16 Mb

Chr 2: 150.44 - 150.46 Mb

Pubmed search

[1]

[2]

Ectonucleoside triphosphate diphosphohydrolase 6 (putative function), also known as ENTPD6, is a human gene.^[1]

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which is characteristic of NTPases.^[1]

[edit] References

^ ^a ^b Entrez Gene: ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative function).

[edit] Further reading

Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes.". Mamm. Genome 8 (9): 668-72. PMID 9271669.
Chadwick BP, Frischauf AM (1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.". Genomics 50 (3): 357-67. doi:10.1006/geno.1998.5317. PMID 9676430.
Hicks-Berger CA, Chadwick BP, Frischauf AM, Kirley TL (2000). "Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2).". J. Biol. Chem. 275 (44): 34041-5. doi:10.1074/jbc.M004723200. PMID 10948193.
Yeung G, Mulero JJ, McGowan DW, et al. (2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart.". Biochemistry 39 (42): 12916-23. PMID 11041856.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ivanenkov VV, Murphy-Piedmonte DM, Kirley TL (2004). "Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function.". Biochemistry 42 (40): 11726-35. doi:10.1021/bi035137r. PMID 14529283.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.