ENTPD2

From Wikipedia, the free encyclopedia

Ectonucleoside triphosphate diphosphohydrolase 2

Identifiers

ENTPD2; CD39L1; NTPDase-2

External IDs

OMIM: 602012 MGI: 1096863 HomoloGene: 20333

Gene ontology
Molecular Function:	• magnesium ion binding • calcium ion binding • protein binding • hydrolase activity • nucleoside-diphosphatase activity • nucleoside-triphosphatase activity
Cellular Component:	• basal lamina • membrane • integral to membrane
Biological Process:	• G-protein coupled receptor protein signaling pathway • purine ribonucleoside diphosphate catabolic process • platelet activation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001246 (mRNA)
NP_001237 (protein)

NM_009849 (mRNA)
NP_033979 (protein)

Location

Chr 9: 139.06 - 139.07 Mb

Chr 2: 25.22 - 25.22 Mb

Pubmed search

[1]

[2]

Ectonucleoside triphosphate diphosphohydrolase 2, also known as ENTPD2, is a human gene.^[1]

The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2.

[edit] Further reading

Javed R, Yarimizu K, Pelletier N, et al. (2007). "Mutagenesis of lysine 62, asparagine 64, and conserved region 1 reduces the activity of human ecto-ATPase (NTPDase 2).". Biochemistry 46 (22): 6617–27. doi:10.1021/bi700036e. PMID 17489562.
Mukasa T, Lee Y, Knowles AF (2005). "Either the carboxyl- or the amino-terminal region of the human ecto-ATPase (E-NTPDase 2) confers detergent and temperature sensitivity to the chicken ecto-ATP-diphosphohydrolase (E-NTPDase 8).". Biochemistry 44 (33): 11160–70. doi:10.1021/bi050019k. PMID 16101300.
Jhandier MN, Kruglov EA, Lavoie EG, et al. (2005). "Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2.". J. Biol. Chem. 280 (24): 22986–92. doi:10.1074/jbc.M412371200. PMID 15799977.
Dranoff JA, Kruglov EA, Toure J, et al. (2005). "Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis.". J. Investig. Med. 52 (7): 475–82. PMID 15651265.
Alvarado-Castillo C, Harden TK, Boyer JL (2005). "Regulation of P2Y1 receptor-mediated signaling by the ectonucleoside triphosphate diphosphohydrolase isozymes NTPDase1 and NTPDase2.". Mol. Pharmacol. 67 (1): 114–22. doi:10.1124/mol.104.006908. PMID 15496502.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Knowles AF, Chiang WC (2003). "Enzymatic and transcriptional regulation of human ecto-ATPase/E-NTPDase 2.". Arch. Biochem. Biophys. 418 (2): 217–27. PMID 14522593.
Mateo J, Kreda S, Henry CE, et al. (2003). "Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme.". J. Biol. Chem. 278 (41): 39960–8. doi:10.1074/jbc.M307854200. PMID 12888562.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Grinthal A, Guidotti G (2002). "Transmembrane domains confer different substrate specificities and adenosine diphosphate hydrolysis mechanisms on CD39, CD39L1, and chimeras.". Biochemistry 41 (6): 1947–56. PMID 11827541.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
Mateo J, Harden TK, Boyer JL (2000). "Functional expression of a cDNA encoding a human ecto-ATPase.". Br. J. Pharmacol. 128 (2): 396–402. doi:10.1038/sj.bjp.0702805. PMID 10510450.
Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes.". Mamm. Genome 8 (9): 668–72. PMID 9271669.