ENPP3

From Wikipedia, the free encyclopedia

Ectonucleotide pyrophosphatase/phosphodiesterase 3

Identifiers

ENPP3; B10; CD203c; NPP3; PD-IBETA; PDNP3

External IDs

OMIM: 602182 MGI: 2143702 HomoloGene: 3683

Gene ontology
Molecular Function:	• nucleic acid binding • endonuclease activity • phosphodiesterase I activity • nucleotide diphosphatase activity • hydrolase activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• phosphate metabolic process • metabolic process • nucleotide metabolic process

Orthologs

Human

Mouse

n/a

Refseq

NM_005021 (mRNA)
NP_005012 (protein)

NM_134005 (mRNA)
NP_598766 (protein)

Location

Chr 6: 132 - 132.11 Mb

Chr 10: 24.46 - 24.53 Mb

Pubmed search

[1]

[2]

Ectonucleotide pyrophosphatase/phosphodiesterase 3, also known as ENPP3, is a human gene.^[1]

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells.^[1]

[edit] References

^ ^a ^b Entrez Gene: ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3.

[edit] Further reading

Bühring HJ, Streble A, Valent P (2004). "The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis.". Int. Arch. Allergy Immunol. 133 (4): 317-29. doi:10.1159/000077351. PMID 15031605.
Jin-Hua P, Goding JW, Nakamura H, Sano K (1998). "Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes.". Genomics 45 (2): 412-5. doi:10.1006/geno.1997.4949. PMID 9344668.
Andoh K, Piao JH, Terashima K, et al. (1999). "Genomic structure and promoter analysis of the ecto-phosphodiesterase I gene (PDNP3) expressed in glial cells.". Biochim. Biophys. Acta 1446 (3): 213-24. PMID 10524196.
Bühring HJ, Seiffert M, Giesert C, et al. (2001). "The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3.". Blood 97 (10): 3303-5. PMID 11342463.
Yano Y, Hayashi Y, Sano K, et al. (2004). "Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma.". Int. J. Mol. Med. 12 (5): 763-6. PMID 14533006.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Yano Y, Hayashi Y, Sano K, et al. (2004). "Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases.". Cancer Lett. 207 (2): 139-47. doi:10.1016/j.canlet.2003.11.002. PMID 15072822.
Elbatarny HS, Maurice DH (2005). "Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex.". Am. J. Physiol. Endocrinol. Metab. 289 (4): E695-702. doi:10.1152/ajpendo.00125.2005. PMID 15886225.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Ocmant A, Peignois Y, Mulier S, et al. (2007). "Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy.". J. Immunol. Methods 320 (1-2): 40-8. doi:10.1016/j.jim.2006.12.002. PMID 17275019.