Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)

From Wikipedia, the free encyclopedia

In enzymology, an enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (EC 1.3.1.10) is an enzyme that catalyzes the chemical reaction

acyl-[acyl-carrier-protein] + NADP⁺ trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH + H⁺

Thus, the two substrates of this enzyme are [[acyl-[acyl-carrier-protein]]] and NADP⁺, whereas its 3 products are [[trans-2,3-dehydroacyl-[acyl-carrier-protein]]], NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (B-specific). Other names in common use include acyl-ACP dehydrogenase, reductase, enoyl-[acyl carrier protein] (reduced nicotinamide, adenine dinucleotide phosphate), NADPH 2-enoyl Co A reductase, enoyl acyl-carrier-protein reductase, enoyl-ACP reductase, and enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific). This enzyme participates in fatty acid biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1ULU and 2YW9.

[edit] References

• IUBMB entry for 1.3.1.10
• BRENDA references for 1.3.1.10 (Recommended.)
• PubMed references for 1.3.1.10
• PubMed Central references for 1.3.1.10
• Google Scholar references for 1.3.1.10
• Saito K, Kawaguchi A, Okuda S, Seyama Y, Yamakawa T (1980). "Incorporation of hydrogen atoms from deuterated water and stereospecifically deuterium-labeled nicotin amide nucleotides into fatty acids with the Escherichia coli fatty acid synthetase system". Biochim. Biophys. Acta. 618: 202–13. PMID 6990992. 
• Seyama Y, Kasama T, Yamakawa T, Kawaguchi A, Saito K (Tokyo). "Origin of hydrogen atoms in the fatty acids synthesized with yeast fatty acid synthetase". J. Biochem.: 1325–9. PMID 338601. 
• Weeks G, Wakil SJ (1968). "Studies on the mechanism of fatty acid synthesis. 18. Preparation and general properties of the enoyl acyl carrier protein reductases from Escherichia coli". J. Biol. Chem. 243: 1180–9. PMID 4384650. 

[edit] External links

The CAS registry number for this enzyme class is 37251-09-5.

• IUBMB entry for 1.3.1.10

• KEGG entry for 1.3.1.10

• BRENDA entry for 1.3.1.10

• NiceZyme view of 1.3.1.10

• EC2PDB: PDB structures for 1.3.1.10

• PRIAM entry for 1.3.1.10

• PUMA2 entry for 1.3.1.10

• IntEnz: Integrated Enzyme entry for 1.3.1.10

• MetaCyc entry for 1.3.1.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004319: enoyl-[acyl-carrier-protein reductase (NADPH, B-specific)]

• AMIGO entry for GO code 0004319: enoyl-[acyl-carrier-protein reductase (NADPH, B-specific)]