Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)

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In enzymology, an enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) (EC 1.3.1.39) is an enzyme that catalyzes the chemical reaction

acyl-[acyl-carrier-protein] + NADP⁺ trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH + H⁺

Thus, the two substrates of this enzyme are [[acyl-[acyl-carrier-protein]]] and NADP⁺, whereas its 3 products are [[trans-2,3-dehydroacyl-[acyl-carrier-protein]]], NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific). Other names in common use include acyl-ACP dehydrogenase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine, dinucleotide phosphate) reductase, NADPH 2-enoyl Co A reductase, enoyl-ACp reductase, and enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific).

[edit] References

• IUBMB entry for 1.3.1.39
• BRENDA references for 1.3.1.39 (Recommended.)
• PubMed references for 1.3.1.39
• PubMed Central references for 1.3.1.39
• Google Scholar references for 1.3.1.39
• Dugan RE, Slakey LL, Porter JW (1970). "Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis". J. Biol. Chem. 245: 6312–6. PMID 4394955. 

[edit] External links

• IUBMB entry for 1.3.1.39

• KEGG entry for 1.3.1.39

• BRENDA entry for 1.3.1.39

• NiceZyme view of 1.3.1.39

• EC2PDB: PDB structures for 1.3.1.39

• PRIAM entry for 1.3.1.39

• PUMA2 entry for 1.3.1.39

• IntEnz: Integrated Enzyme entry for 1.3.1.39

• MetaCyc entry for 1.3.1.39

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047117: enoyl-[acyl-carrier-protein reductase (NADPH, A-specific)]

• AMIGO entry for GO code 0047117: enoyl-[acyl-carrier-protein reductase (NADPH, A-specific)]