Endothelin converting enzyme 1

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Endothelin converting enzyme 1
Identifiers
Symbol(s) ECE1; ECE
External IDs OMIM: 600423 MGI: 1101357 HomoloGene: 1068
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1889 230857
Ensembl ENSG00000117298 ENSMUSG00000057530
Uniprot P42892 Q3TUZ3
Refseq NM_001397 (mRNA)
NP_001388 (protein)		 XM_989734 (mRNA)
XP_994828 (protein)
Location Chr 1: 21.42 - 21.54 Mb Chr 4: 137.13 - 137.24 Mb
Pubmed search [1] [2]

Endothelin converting enzyme 1, also known as ECE1, is a human gene.[1]

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1; MIM 131240), -2 (EDN2; MIM 131241), and -3 (EDN3; MIM 131242) to biologically active peptides.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: ECE1 endothelin converting enzyme 1.

[edit] Further reading

  • Yorimitsu K, Moroi K, Inagaki N, et al. (1995). "Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2.". Biochem. Biophys. Res. Commun. 208 (2): 721-7. PMID 7695628. 
  • Schmidt M, Kröger B, Jacob E, et al. (1995). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1).". FEBS Lett. 356 (2-3): 238-43. PMID 7805846. 
  • Shimada K, Matsushita Y, Wakabayashi K, et al. (1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA.". Biochem. Biophys. Res. Commun. 207 (2): 807-12. doi:10.1006/bbrc.1995.1258. PMID 7864876. 
  • Valdenaire O, Rohrbacher E, Mattei MG (1996). "Organization of the gene encoding the human endothelin-converting enzyme (ECE-1).". J. Biol. Chem. 270 (50): 29794-8. PMID 8530372. 
  • Matsuoka R, Sawamura T, Yamada K, et al. (1996). "Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1.". Cytogenet. Cell Genet. 72 (4): 322-4. PMID 8641140. 
  • Orzechowski HD, Richter CM, Funke-Kaiser H, et al. (1997). "Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells.". J. Mol. Med. 75 (7): 512-21. PMID 9253714. 
  • Schweizer A, Valdenaire O, Nelböck P, et al. (1998). "Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations.". Biochem. J. 328 ( Pt 3): 871-7. PMID 9396733. 
  • Kido T, Sawamura T, Masaki T (1998). "The processing pathway of endothelin-1 production.". J. Cardiovasc. Pharmacol. 31 Suppl 1: S13-5. PMID 9595387. 
  • Hofstra RM, Valdenaire O, Arch E, et al. (1999). "A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction.". Am. J. Hum. Genet. 64 (1): 304-8. PMID 9915973. 
  • Lee S, Lin M, Mele A, et al. (1999). "Proteolytic processing of big endothelin-3 by the kell blood group protein.". Blood 94 (4): 1440-50. PMID 10438732. 
  • Valdenaire O, Lepailleur-Enouf D, Egidy G, et al. (1999). "A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization.". Eur. J. Biochem. 264 (2): 341-9. PMID 10491078. 
  • Fahnoe DC, Johnson GD, Herman SB, Ahn K (2000). "Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells.". Arch. Biochem. Biophys. 373 (2): 385-93. doi:10.1006/abbi.1999.1586. PMID 10620363. 
  • López-Ongil S, Senchak V, Saura M, et al. (2000). "Superoxide regulation of endothelin-converting enzyme.". J. Biol. Chem. 275 (34): 26423-7. doi:10.1074/jbc.M000767200. PMID 10833511. 
  • Hachiya A, Kobayashi T, Takema Y, Imokawa G (2002). "Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis.". J. Biol. Chem. 277 (7): 5395-403. doi:10.1074/jbc.M105874200. PMID 11723113. 
  • Inguimbert N, Coric P, Poras H, et al. (2002). "Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).". J. Med. Chem. 45 (7): 1477-86. PMID 11906289. 
  • MacLeod KJ, Husain RD, Gage DA, Ahn K (2003). "Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms.". J. Biol. Chem. 277 (48): 46355-63. doi:10.1074/jbc.M207972200. PMID 12244060. 
  • Muller L, Barret A, Etienne E, et al. (2003). "Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease.". J. Biol. Chem. 278 (1): 545-55. doi:10.1074/jbc.M208949200. PMID 12393864. 
  • Eckman EA, Watson M, Marlow L, et al. (2003). "Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.". J. Biol. Chem. 278 (4): 2081-4. doi:10.1074/jbc.C200642200. PMID 12464614. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Masatsugu K, Itoh H, Chun TH, et al. (2003). "Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress.". Regul. Pept. 111 (1-3): 13-9. PMID 12609744. 
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