Endothelin 1

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Endothelin 1
Identifiers
Symbol(s)	EDN1; ET1
External IDs	OMIM: 131240 MGI: 95283 HomoloGene: 1476
Gene ontology Molecular Function: • hormone activity • endothelin A receptor binding Cellular Component: • extracellular region • extracellular space • soluble fraction Biological Process: • patterning of blood vessels • response to hypoxia • in utero embryonic development • regulation of pH • signal transduction • protein kinase C activation • cell-cell signaling • heart development • respiratory gaseous exchange • fluid secretion • blood pressure regulation • positive regulation of cell proliferation • pathogenesis • dorsal/ventral pattern formation • neural crest cell development • glucose transport • regulation of vasoconstriction • diuresis • natriuresis • negative regulation of cAMP biosynthetic process • G-protein signaling, phospholipase D activating pathway • middle ear morphogenesis • rhythmic excitation • positive regulation of smooth muscle contraction • blood vessel morphogenesis • cartilage development • elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1906	13614
Ensembl	ENSG00000078401	ENSMUSG00000021367
Uniprot	P05305	Q544E0
Refseq	NM_001955 (mRNA) NP_001946 (protein)	NM_010104 (mRNA) NP_034234 (protein)
Location	Chr 6: 12.4 - 12.41 Mb	Chr 13: 42.31 - 42.32 Mb
Pubmed search	[1]	[2]

Endothelin 1, also known as EDN1, is a human gene and the corresponding peptide, one of three isoforms of human endothelin.

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