Endoglycosylceramidase

From Wikipedia, the free encyclopedia

In enzymology, an endoglycosylceramidase (EC 3.2.1.123) is an enzyme that catalyzes the chemical reaction

oligoglycosylglucosylceramide + H₂O ceramide + oligoglycosylglucose

Thus, the two substrates of this enzyme are oligoglycosylglucosylceramide and H₂O, whereas its two products are ceramide and oligoglycosylglucose.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is oligoglycosylglucosylceramide glycohydrolase. Other names in common use include endoglycoceramidase, EGCase, and glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2OSW, 2OSX, 2OSY, 2OYK, 2OYL, and 2OYM.

[edit] References

• IUBMB entry for 3.2.1.123
• BRENDA references for 3.2.1.123 (Recommended.)
• PubMed references for 3.2.1.123
• PubMed Central references for 3.2.1.123
• Google Scholar references for 3.2.1.123
• Ito M, Yamagata T (1986). "A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids". J. Biol. Chem. 261: 14278–82. PMID 3771534. 

[edit] External links

The CAS registry number for this enzyme class is 105503-61-5.

• IUBMB entry for 3.2.1.123

• KEGG entry for 3.2.1.123

• BRENDA entry for 3.2.1.123

• NiceZyme view of 3.2.1.123

• EC2PDB: PDB structures for 3.2.1.123

• PRIAM entry for 3.2.1.123

• PUMA2 entry for 3.2.1.123

• IntEnz: Integrated Enzyme entry for 3.2.1.123

• MetaCyc entry for 3.2.1.123

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047876: endoglycosylceramidase

• AMIGO entry for GO code 0047876: endoglycosylceramidase