Endogenous mediator

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Endogenous mediators are intracellular proteins that enhance and activate the functions of other proteins. This term is commonly used in molecular biology and cell biology to describe a specific protein complex that acts in transcription as a coactivator. This Mediator complex is located within the cell nucleus.

The Mediator complex is required for the successful transcription of nearly all class II gene promoters in yeast.[1] It works in the same manner in mammals. The mediator functions as a coactivator and binds to the C-terminal domain of RNA polymerase II holoenzyme, acting as a bridge between this enzyme and transcription factors.[2]

[edit] References

  1. ^ Biddick R, Young ET (2005). "Yeast mediator and its role in transcriptional regulation". C. R. Biol. 328 (9): 773–82. doi:10.1016/j.crvi.2005.03.004. PMID 16168358. 
  2. ^ Björklund S, Gustafsson CM (2005). "The yeast Mediator complex and its regulation". Trends Biochem. Sci. 30 (5): 240–4. doi:10.1016/j.tibs.2005.03.008. PMID 15896741. 


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