ENDOG

From Wikipedia, the free encyclopedia

Endonuclease G

Identifiers

ENDOG; FLJ27463

External IDs

OMIM: 600440 MGI: 1261433 HomoloGene: 55823

Gene ontology
Molecular Function:	• magnesium ion binding • DNA binding • endonuclease activity • hydrolase activity • manganese ion binding
Cellular Component:	• mitochondrion
Biological Process:	• DNA metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004435 (mRNA)
NP_004426 (protein)

NM_007931 (mRNA)
NP_031957 (protein)

Location

Chr 9: 130.62 - 130.62 Mb

Chr 2: 29.99 - 30 Mb

Pubmed search

[1]

[2]

Endonuclease G, also known as ENDOG, is a human gene.^[1]

The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA.^[1]

[edit] References

^ ^a ^b Entrez Gene: ENDOG endonuclease G.

[edit] Further reading

Tiranti V, Rossi E, Ruiz-Carrillo A, et al. (1995). "Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis.". Genomics 25 (2): 559-64. PMID 7789991.
Prats E, Noël M, Létourneau J, et al. (1997). "Characterization and expression of the mouse endonuclease G gene.". DNA Cell Biol. 16 (9): 1111-22. PMID 9324313.
Li LY, Luo X, Wang X (2001). "Endonuclease G is an apoptotic DNase when released from mitochondria.". Nature 412 (6842): 95-9. doi:10.1038/35083620. PMID 11452314.
Ohsato T, Ishihara N, Muta T, et al. (2003). "Mammalian mitochondrial endonuclease G. Digestion of R-loops and localization in intermembrane space.". Eur. J. Biochem. 269 (23): 5765-70. PMID 12444964.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lemarié A, Lagadic-Gossmann D, Morzadec C, et al. (2005). "Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor.". Free Radic. Biol. Med. 36 (12): 1517-31. doi:10.1016/j.freeradbiomed.2004.03.020. PMID 15182854.
Singh IN, Goody RJ, Dean C, et al. (2004). "Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G.". J. Neurovirol. 10 (3): 141-51. doi:10.1080/13550280490441103. PMID 15204919.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kalinowska M, Garncarz W, Pietrowska M, et al. (2007). "Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP.". Apoptosis 10 (4): 821-30. doi:10.1007/s10495-005-0410-9. PMID 16133872.
Basnakian AG, Apostolov EO, Yin X, et al. (2007). "Endonuclease G promotes cell death of non-invasive human breast cancer cells.". Exp. Cell Res. 312 (20): 4139-49. doi:10.1016/j.yexcr.2006.09.012. PMID 17046751.
Whiteman M, Chu SH, Siau JL, et al. (2007). "The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways.". Cell. Signal. 19 (4): 705-14. doi:10.1016/j.cellsig.2006.08.019. PMID 17107772.
Varecha M, Amrichová J, Zimmermann M, et al. (2007). "Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells.". Apoptosis 12 (7): 1155-71. doi:10.1007/s10495-007-0061-0. PMID 17347867.