Enamidase

From Wikipedia, the free encyclopedia

In enzymology, an enamidase (EC 3.5.2.18) is an enzyme that catalyzes the chemical reaction

6-oxo-1,4,5,6-tetrahydronicotinate + 2 H₂O 2-formylglutarate + NH₃

Thus, the two substrates of this enzyme are 6-oxo-1,4,5,6-tetrahydronicotinate and H₂O, whereas its two products are 2-formylglutarate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase.

[edit] References

• IUBMB entry for 3.5.2.18
• BRENDA references for 3.5.2.18 (Recommended.)
• PubMed references for 3.5.2.18
• PubMed Central references for 3.5.2.18
• Google Scholar references for 3.5.2.18
• Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ (2006). "Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri". Proc. Natl. Acad. Sci. U. S. A. 103: 12341–6. doi:10.1073/pnas.0601635103. PMID 16894175. 

[edit] External links

• IUBMB entry for 3.5.2.18

• KEGG entry for 3.5.2.18

• BRENDA entry for 3.5.2.18

• NiceZyme view of 3.5.2.18

• EC2PDB: PDB structures for 3.5.2.18

• PRIAM entry for 3.5.2.18

• PUMA2 entry for 3.5.2.18

• IntEnz: Integrated Enzyme entry for 3.5.2.18

• MetaCyc entry for 3.5.2.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043792: enamidase

• AMIGO entry for GO code 0043792: enamidase