EMR3
From Wikipedia, the free encyclopedia
Egf-like module containing, mucin-like, hormone receptor-like 3
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Identifiers | ||||||||||||||
Symbol(s) | EMR3; | |||||||||||||
External IDs | OMIM: 606101 HomoloGene: 50009 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 84658 | n/a | ||||||||||||
Ensembl | ENSG00000131355 | n/a | ||||||||||||
Uniprot | Q9BY15 | n/a | ||||||||||||
Refseq | NM_032571 (mRNA) NP_115960 (protein) |
n/a (mRNA) n/a (protein) |
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Location | Chr 19: 14.57 - 14.65 Mb | n/a | ||||||||||||
Pubmed search | [1] | n/a |
Egf-like module containing, mucin-like, hormone receptor-like 3, also known as EMR3, is a human gene.[1]
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[1]
[edit] See also
[edit] References
[edit] Further reading
- Stacey M, Lin HH, Hilyard KL, et al. (2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils.". J. Biol. Chem. 276 (22): 18863–70. doi: . PMID 11279179.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: . PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi: . PMID 12975309.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi: . PMID 15203201.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi: . PMID 17081983.
- Matmati M, Pouwels W, van Bruggen R, et al. (2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.". J. Leukoc. Biol. 81 (2): 440–8. doi: . PMID 17108056.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.