EMR1
From Wikipedia, the free encyclopedia
Egf-like module containing, mucin-like, hormone receptor-like 1
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Identifiers | ||||||||||||||
Symbol(s) | EMR1; TM7LN3 | |||||||||||||
External IDs | OMIM: 600493 MGI: 106912 HomoloGene: 1493 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 2015 | 13733 | ||||||||||||
Ensembl | ENSG00000174837 | ENSMUSG00000004730 | ||||||||||||
Uniprot | Q14246 | Q3S4B0 | ||||||||||||
Refseq | NM_001974 (mRNA) NP_001965 (protein) |
NM_010130 (mRNA) NP_034260 (protein) |
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Location | Chr 19: 6.84 - 6.89 Mb | Chr 17: 57.04 - 57.17 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Egf-like module containing, mucin-like, hormone receptor-like 1, also known as EMR1, is a human gene.[1]
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.[1]
[edit] See also
[edit] References
[edit] Further reading
- McKnight AJ, Gordon S (1998). "The EGF-TM7 family: unusual structures at the leukocyte surface.". J. Leukoc. Biol. 63 (3): 271–80. PMID 9500513.
- Baud V, Chissoe SL, Viegas-Péquignot E, et al. (1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments.". Genomics 26 (2): 334–44. PMID 7601460.
- McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S (1998). "Chromosome mapping of the Emr1 gene.". Mamm. Genome 8 (12): 946. PMID 9383301.
- Carver EA, Hamann J, Olsen AS, Stubbs L (2000). "Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication.". Mamm. Genome 10 (10): 1039–40. PMID 10501980.
- Lin HH, Stacey M, Hamann J, et al. (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97.". Genomics 67 (2): 188–200. doi: . PMID 10903844.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: . PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi: . PMID 15489334.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.