EMCN

From Wikipedia, the free encyclopedia

Endomucin

Identifiers

EMCN; EMCN2; MUC14

External IDs

OMIM: 608350 MGI: 1891716 HomoloGene: 9438

Gene ontology
Molecular Function:	• carbohydrate binding
Cellular Component:	• plasma membrane • external side of plasma membrane • membrane • integral to membrane
Biological Process:	• angiogenesis • cell-cell adhesion • regulation of cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016242 (mRNA)
NP_057326 (protein)

NM_016885 (mRNA)
NP_058581 (protein)

Location

Chr 4: 101.54 - 101.66 Mb

Chr 3: 137.28 - 137.37 Mb

Pubmed search

[1]

[2]

Endomucin, also known as EMCN, is a human gene.^[1]

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: EMCN endomucin.

[edit] Further reading

Li G, Miles A, Line A, Rees RC (2004). "Identification of tumour antigens by serological analysis of cDNA expression cloning.". Cancer Immunol. Immunother. 53 (3): 139–43. doi:10.1007/s00262-003-0471-y. PMID 14722670.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kinoshita M, Nakamura T, Ihara M, et al. (2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity.". FEBS Lett. 499 (1-2): 121–6. PMID 11418125.
Liu C, Shao ZM, Zhang L, et al. (2001). "Human endomucin is an endothelial marker.". Biochem. Biophys. Res. Commun. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
Samulowitz U, Kuhn A, Brachtendorf G, et al. (2002). "Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope.". Am. J. Pathol. 160 (5): 1669–81. PMID 12000719.
Linē A, Stengrēvics A, Slucka Z, et al. (2002). "Serological identification and expression analysis of gastric cancer-associated genes.". Br. J. Cancer 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMID 12087473.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kuhn A, Brachtendorf G, Kurth F, et al. (2003). "Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin.". J. Invest. Dermatol. 119 (6): 1388–93. doi:10.1046/j.1523-1747.2002.19647.x. PMID 12485444.
Kanda H, Tanaka T, Matsumoto M, et al. (2005). "Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling.". Int. Immunol. 16 (9): 1265–74. doi:10.1093/intimm/dxh128. PMID 15249540.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.