ELP4

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Elongation protein 4 homolog (S. cerevisiae)
Identifiers
Symbol(s) ELP4; C11orf19; FLJ20498; PAX6NEB; PAXNEB; dJ68P15A.1
External IDs OMIM: 606985 MGI: 1925016 HomoloGene: 32433
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 26610 77766
Ensembl ENSG00000109911 ENSMUSG00000027167
Refseq NM_019040 (mRNA)
NP_061913 (protein)		 NM_023876 (mRNA)
NP_076365 (protein)
Location Chr 11: 31.49 - 31.76 Mb Chr 2: 105.5 - 105.71 Mb
Pubmed search [1] [2]

Elongation protein 4 homolog (S. cerevisiae), also known as ELP4, is a human gene.[1]

This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: ELP4 elongation protein 4 homolog (S. cerevisiae).

[edit] Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Winkler GS, Petrakis TG, Ethelberg S, et al. (2001). "RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes.". J. Biol. Chem. 276 (35): 32743–9. doi:10.1074/jbc.M105303200. PMID 11435442. 
  • Hawkes NA, Otero G, Winkler GS, et al. (2002). "Purification and characterization of the human elongator complex.". J. Biol. Chem. 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725. 
  • Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin.". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. doi:10.1073/pnas.251672198. PMID 11818576. 
  • Kleinjan DA, Seawright A, Elgar G, van Heyningen V (2002). "Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance.". Mamm. Genome 13 (2): 102–7. doi:10.1007/s00335-001-3058-y. PMID 11889558. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Li F, Han QJ, Luo DH, et al. (2004). "[The Elp4 subunit of human Elongator complex partially complements the growth defects of yeast ELP4 deletion strain]". Yi Chuan Xue Bao 31 (7): 668–74. PMID 15473317. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901. 
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