ELMO1

From Wikipedia, the free encyclopedia

Engulfment and cell motility 1

Identifiers

ELMO1; CED-12; CED12; ELMO-1; KIAA0281; MGC126406

External IDs

OMIM: 606420 MGI: 2153044 HomoloGene: 56685

Gene ontology
Molecular Function:	• protein binding • SH3 domain binding
Cellular Component:	• cytoplasm • cytoskeleton • plasma membrane
Biological Process:	• phagocytosis • phagocytosis, engulfment • apoptosis • cell motility • Rac protein signal transduction • actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001039459 (mRNA)
NP_001034548 (protein)

NM_080288 (mRNA)
NP_525027 (protein)

Location

Chr 7: 36.86 - 37.45 Mb

Chr 13: 20.1 - 20.61 Mb

Pubmed search

[1]

[2]

Engulfment and cell motility 1, also known as ELMO1, is a human gene.^[1]

The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. Similarity to a C. elegans protein suggests that this protein may function in apoptosis and in cell migration. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: ELMO1 engulfment and cell motility 1.

[edit] Further reading

Ohara O, Nagase T, Ishikawa K, et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.". DNA Res. 4 (1): 53–9. PMID 9179496.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Gumienny TL, Brugnera E, Tosello-Trampont AC, et al. (2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.". Cell 107 (1): 27–41. PMID 11595183.
Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
Brugnera E, Haney L, Grimsley C, et al. (2002). "Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.". Nat. Cell Biol. 4 (8): 574–82. doi:10.1038/ncb824. PMID 12134158.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Sanui T, Inayoshi A, Noda M, et al. (2003). "DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1.". Blood 102 (8): 2948–50. doi:10.1182/blood-2003-01-0173. PMID 12829596.
Katoh H, Negishi M (2003). "RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.". Nature 424 (6947): 461–4. doi:10.1038/nature01817. PMID 12879077.
Grimsley CM, Kinchen JM, Tosello-Trampont AC, et al. (2004). "Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.". J. Biol. Chem. 279 (7): 6087–97. doi:10.1074/jbc.M307087200. PMID 14638695.
Wang X, Wu YC, Fadok VA, et al. (2003). "Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.". Science 302 (5650): 1563–6. doi:10.1126/science.1087641. PMID 14645848.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Janardhan A, Swigut T, Hill B, et al. (2006). "HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis.". PLoS Biol. 2 (1): E6. doi:10.1371/journal.pbio.0020006. PMID 14737186.
Lu M, Kinchen JM, Rossman KL, et al. (2004). "PH domain of ELMO functions in trans to regulate Rac activation via Dock180.". Nat. Struct. Mol. Biol. 11 (8): 756–62. doi:10.1038/nsmb800. PMID 15247908.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
deBakker CD, Haney LB, Kinchen JM, et al. (2005). "Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO.". Curr. Biol. 14 (24): 2208–16. doi:10.1016/j.cub.2004.12.029. PMID 15620647.
Akakura S, Kar B, Singh S, et al. (2005). "C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF.". J. Cell. Physiol. 204 (1): 344–51. doi:10.1002/jcp.20288. PMID 15700267.
Lu M, Kinchen JM, Rossman KL, et al. (2005). "A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.". Curr. Biol. 15 (4): 371–7. doi:10.1016/j.cub.2005.01.050. PMID 15723800.
Shimazaki A, Kawamura Y, Kanazawa A, et al. (2005). "Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy.". Diabetes 54 (4): 1171–8. PMID 15793258.
Yokoyama N, deBakker CD, Zappacosta F, et al. (2005). "Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.". Biochemistry 44 (24): 8841–9. doi:10.1021/bi0500832. PMID 15952790.