ELAVL4

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ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
PDB rendering based on 1d8z.
Available structures: 1d8z, 1d9a, 1fnx, 1fxl, 1g2e
Identifiers
Symbol(s) ELAVL4; HUD; PNEM
External IDs OMIM: 168360 MGI: 107427 HomoloGene: 40729
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1996 15572
Ensembl ENSG00000162374 ENSMUSG00000028546
Uniprot P26378 Q1KS26
Refseq NM_021952 (mRNA)
NP_068771 (protein)		 NM_001038698 (mRNA)
NP_001033787 (protein)
Location Chr 1: 50.34 - 50.44 Mb Chr 4: 109.7 - 109.79 Mb
Pubmed search [1] [2]

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D), also known as ELAVL4, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D).

[edit] Further reading

  • Dalmau J, Furneaux HM, Cordon-Cardo C, Posner JB (1992). "The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues.". Am. J. Pathol. 141 (4): 881–6. PMID 1415481. 
  • Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.". Cell 67 (2): 325–33. PMID 1655278. 
  • Graus F, Ferrer I (1990). "Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis.". Neurosci. Lett. 112 (1): 14–8. PMID 2166930. 
  • Sekido Y, Bader SA, Carbone DP, et al. (1994). "Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines.". Cancer Res. 54 (18): 4988–92. PMID 8069866. 
  • Muresu R, Baldini A, Gress T, et al. (1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34.". Cytogenet. Cell Genet. 65 (3): 177–8. PMID 8222755. 
  • Torà M, Graus F, de Bolòs C, Real FX (1997). "Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas.". Neurology 48 (3): 735–41. PMID 9065557. 
  • Lazarova DL, Spengler BA, Biedler JL, Ross RA (1999). "HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts.". Oncogene 18 (17): 2703–10. doi:10.1038/sj.onc.1202621. PMID 10348344. 
  • Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.". Mol. Cell. Biol. 20 (13): 4765–72. PMID 10848602. 
  • Wang X, Tanaka Hall TM (2001). "Structural basis for recognition of AU-rich element RNA by the HuD protein.". Nat. Struct. Biol. 8 (2): 141–5. doi:10.1038/84131. PMID 11175903. 
  • Beckel-Mitchener AC, Miera A, Keller R, Perrone-Bizzozero NI (2002). "Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD.". J. Biol. Chem. 277 (31): 27996–8002. doi:10.1074/jbc.M201982200. PMID 12034726. 
  • Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library.". Int. J. Cancer 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604. 
  • Aronov S, Aranda G, Behar L, Ginzburg I (2003). "Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules.". J. Cell. Sci. 115 (Pt 19): 3817–27. PMID 12235292. 
  • Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons.". J. Neurosci. 22 (20): 8827–37. PMID 12388589. 
  • Deschenes-Furry J, Belanger G, Perrone-Bizzozero N, Jasmin BJ (2003). "Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD.". J. Biol. Chem. 278 (8): 5710–7. doi:10.1074/jbc.M209383200. PMID 12468554. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Plonquet A, Garcia-Pons F, Fernandez E, et al. (2004). "Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human.". J. Neuroimmunol. 142 (1-2): 93–100. PMID 14512168. 
  • Saito K, Fujiwara T, Katahira J, et al. (2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD.". Biochem. Biophys. Res. Commun. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. PMID 15358174. 
  • Rousseau A, Benyahia B, Dalmau J, et al. (2005). "T cell response to Hu-D peptides in patients with anti-Hu syndrome.". J. Neurooncol. 71 (3): 231–6. doi:10.1007/s11060-004-1723-1. PMID 15735910. 
  • Noureddine MA, Qin XJ, Oliveira SA, et al. (2005). "Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease.". Hum. Genet. 117 (1): 27–33. doi:10.1007/s00439-005-1259-2. PMID 15827745. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
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