ELAVL2

From Wikipedia, the free encyclopedia

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)

PDB rendering based on 1d8z.

Available structures: 1d8z, 1d9a, 1fnx, 1fxl, 1g2e

Identifiers

Symbol(s)

ELAVL2; HEL-N1; HELN1; HUB

External IDs

OMIM: 601673 MGI: 1100887 HomoloGene: 20930

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • mRNA 3'-UTR binding
Biological Process:	• regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004432 (mRNA)
NP_004423 (protein)

NM_010486 (mRNA)
NP_034616 (protein)

Location

Chr 9: 23.68 - 23.82 Mb

Chr 4: 90.74 - 90.89 Mb

Pubmed search

[1]

[2]

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B), also known as ELAVL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B).

[edit] Further reading

Gao FB, Carson CC, Levine T, Keene JD (1994). "Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11207–11. PMID 7972035.
King PH, Levine TD, Fremeau RT, Keene JD (1994). "Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.". J. Neurosci. 14 (4): 1943–52. PMID 8158249.
Han J, Knops JF, Longshore JW, King PH (1997). "Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization.". Genomics 36 (1): 189–91. doi:10.1006/geno.1996.0444. PMID 8812435.
Gao FB, Keene JD (1997). "Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.". J. Cell. Sci. 109 ( Pt 3): 579–89. PMID 8907704.
Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA.". Mol. Cell. Biol. 20 (13): 4765–72. PMID 10848602.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yano M, Okano HJ, Okano H (2005). "Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation.". J. Biol. Chem. 280 (13): 12690–9. doi:10.1074/jbc.M411119200. PMID 15671036.