ELA2A

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Elastase 2A
Identifiers
Symbol(s) ELA2A; ELA1; PE-1
External IDs OMIM: 609443 MGI: 95316 HomoloGene: 40598
Orthologs
Human Mouse
Entrez 63036 13706
Ensembl n/a ENSMUSG00000058579
Uniprot n/a P05208
Refseq NM_033440 (mRNA)
NP_254275 (protein)		 NM_007919 (mRNA)
NP_031945 (protein)
Location n/a Chr 4: 141.09 - 141.1 Mb
Pubmed search [1] [2]

Elastase 2A, also known as ELA2A, is a human gene.[1]

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.[1]

[edit] References

  1. ^ a b Entrez Gene: ELA2A elastase 2A.

[edit] Further reading

  • Moulard M, Michon T, Kerfelec B, Chapus C (1990). "Further studies on the human pancreatic binary complexes involving procarboxypeptidase A.". FEBS Lett. 261 (1): 179–83. PMID 2307232. 
  • Shirasu Y, Yoshida H, Matsuki S, et al. (1988). "Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2.". J. Biochem. 102 (6): 1555–63. PMID 2834346. 
  • Fletcher TS, Shen WF, Largman C (1988). "Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.". Biochemistry 26 (23): 7256–61. PMID 3427074. 
  • Kawashima I, Tani T, Shimoda K, Takiguchi Y (1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.". DNA 6 (2): 163–72. PMID 3646943. 
  • Friess H, Ding J, Kleeff J, et al. (2002). "Identification of disease-specific genes in chronic pancreatitis using DNA array technology.". Ann. Surg. 234 (6): 769–78; discussion 778–9. PMID 11729383. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Lausen J, Liu S, Fliegauf M, et al. (2006). "ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO.". Oncogene 25 (9): 1349–57. doi:10.1038/sj.onc.1209181. PMID 16247445. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
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